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Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB<jats:sub>1<\/jats:sub>R and CB<jats:sub>2<\/jats:sub>R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB<jats:sub>1<\/jats:sub>R and CB<jats:sub>2<\/jats:sub>R and their interaction in the modulation of psychostimulant responses.<\/jats:p>","DOI":"10.1017\/neu.2022.23","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T09:45:35Z","timestamp":1661161535000},"page":"67-77","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant 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