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VCM and oxidative stress parameters were assessed at different time points after the last dose of medication.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270822000291_as3\"><jats:title>Results:<\/jats:title><jats:p>Oral CBD (5 mg\/kg) attenuated the VCM produced by sub-chronic administration of haloperidol (5 mg\/kg) but had minimal effects on the VCM produced by chronic administration of haloperidol (50 mg\/kg). In both sub-chronic and chronic haloperidol groups, there were significant changes in brain antioxidant parameters compared with CBD only and the control groups. The sub-chronic haloperidol-only group had lower glutathione activity compared with sub-chronic haloperidol before CBD and the control groups; also, superoxide dismutase, catalase, and 2,2-diphenyl-1-picrylhydrazyl activities were increased in the sub-chronic (IP) haloperidol only group compared with the CBD only and control groups. Nitric oxide activity was increased in sub-chronic haloperidol-only group compared to the other groups; however, the chronic haloperidol group had increased malondialdehyde activity compared to the other groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270822000291_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Our findings indicate that CBD ameliorated VCM in the sub-chronic haloperidol group before CBD, but marginally in the chronic haloperidol group before CBD. 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