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We also investigated the CBD effect on anxiety-like responses.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000133_as2\"><jats:title>Methods:<\/jats:title><jats:p>After T1DM induction, animals received single or more prolonged treatment with CBD and were submitted to the contextual fear conditioning test. As expression of activity-regulated cytoskeletal-associated (Arc) protein is necessary for memory consolidation, we evaluated its expression in the dorsal hippocampus (DH). For evaluating anxiety-related responses, animals were submitted to the elevated plus maze test (EPMT), in which the time and number of entries in the open arms were used as anxiety index.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000133_as3\"><jats:title>Results:<\/jats:title><jats:p>A single injection of CBD impaired the contextual fear memory consolidation and its generalisation, which was evaluated by exposing the animal in a neutral context. This single injection was able to reduce the elevated expression of Arc in the DH from these animals. Interestingly, more prolonged treatment with CBD also impaired the persistence of context-conditioned fear memory and induced an anxiolytic-like effect, as the treated group spent more time in the open arms of the EPMT.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000133_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>CBD interferes with contextual fear memory and the dosage regimen of treatment seems to be important. Moreover, we cannot rule out the involvement of emotional aspects in these processes related to fear memory.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2023.13","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T09:56:29Z","timestamp":1676886989000},"page":"276-286","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes <i>mellitus<\/i>"],"prefix":"10.1017","volume":"36","author":[{"given":"Yane Costa","family":"Chaves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Raymundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula 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