{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:30:37Z","timestamp":1790742637536,"version":"4.1.0"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0924270823000248_as1\"><jats:title>Introduction:<\/jats:title><jats:p>A dysbalance of the immune system in psychotic disorders has been well investigated. However, despite a higher prevalence of cannabis (THC) consumption in patients with psychosis, few studies have investigated the impact of this use on inflammatory markers.<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000248_as2\"><jats:title>Methods:<\/jats:title><jats:p>One hundred and two inpatients were included in this retrospective study. Leukocytic formula, hsCRP, fibrinogen levels and urinary THC were measured, and comparisons were performed at baseline and after 4 weeks of cannabis cessation between cannabis users (THC+) and non-users (THC\u2212).<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000248_as3\"><jats:title>Results:<\/jats:title><jats:p>After cannabis cessation, we found a greater increase in leucocyte level (<jats:italic>p<\/jats:italic> &lt; 0.01), monocyte level (<jats:italic>p<\/jats:italic> = 0.05) and a statistical trend to a highest increase of lymphocyte level (<jats:italic>p<\/jats:italic> = 0.06) between baseline and 4 weeks in the THC+ group as compared to the THC\u2212 group. At 4 weeks, highest leucocyte (<jats:italic>p<\/jats:italic> = 0.03), lymphocyte (<jats:italic>p<\/jats:italic> = 0.04) and monocyte (<jats:italic>p<\/jats:italic> &lt; 0.01) counts were found in the THC+ group, whereas at baseline no difference was found. A positive correlation was found between monocyte count at 4 weeks and baseline Positive and Negative Syndrome Scale (PANSS) negative subscore (<jats:italic>p<\/jats:italic> = 0.045) and between the variation of monocyte count between baseline and 4 weeks and the PANSS total score at 4 weeks (<jats:italic>p<\/jats:italic> = 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0924270823000248_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>THC cessation is associated with an increase in inflammatory markers, including white blood cell, lymphocyte and monocyte levels, which correlates with symptomatology of patients with psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/neu.2023.24","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:19:01Z","timestamp":1682669941000},"page":"118-127","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Increased markers of inflammation after cannabis cessation 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