{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:27:07Z","timestamp":1784309227738,"version":"3.55.0"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S092427082300025X_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092427082300025X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND\/mild cognitive impairment\/other neurological disorders (ND\/MCI\/other) and PSY. We pre-specified NfL &gt; 582 pg\/mL as indicative of ND\/MCI\/other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092427082300025X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Diagnostic category changed from initial to final diagnosis for 23% (49\/212) of patients. NfL predicted the final diagnostic category for 92% (22\/24) of these and predicted final diagnostic category overall (ND\/MCI\/other vs. PSY) in 88% (187\/212), compared to 77% (163\/212) with clinical assessment alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S092427082300025X_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2023.25","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:04:12Z","timestamp":1682654652000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-3762","authenticated-orcid":false,"given":"Matthew J. 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