{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:51:13Z","timestamp":1778323873200,"version":"3.51.4"},"reference-count":75,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924270823000558_as1\">\n\t    <jats:title>Objectives:<\/jats:title>\n\t    <jats:p>Recent studies have shown that the distribution of the tryptophan\/kynurenine pathway (KP) plays a role in the development of obsessive-compulsive disorder (OCD). We aimed to reveal the relationship between CYP1A1 rs464903 and aryl hydrocarbon receptor (AhR) rs10249788 associated with the KP and interferon gamma (IFN \u03b3) and oxidative stress in OCD.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270823000558_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>In our study, the serum and DNAs of 150 samples, including 100 OCD patients and 50 controls, were used. The activity of glutathione peroxidase (GSH-Px), and the levels of IFN \u03b3, thiobarbituric acid reactive substances (TBARS), tryptophan, and kynurenine were determined by biochemical methods. AhR rs10249788 and cytochrome P450 family CYP1A1 rs4646903, which interact directly with the KP, were analysed by polymerase chain reaction followed by restriction fragment length polymorphism. <jats:italic>P<\/jats:italic> &lt; 0.05 was considered statistically significant.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270823000558_as3\">\n\t    <jats:title>Result:<\/jats:title>\n\t    <jats:p>There were no significant differences between groups in CYP1A1 rs4646903 and AhR rs10249788 while tryptophan and IFN \u03b3 were found to be higher in controls (<jats:italic>p<\/jats:italic> &lt; 0.001, for both), and TBARS and indolamine-2,3-dioxygenase were found to be higher in OCD (<jats:italic>p<\/jats:italic> &lt; 0.001, for both). There were significant correlations between IFN \u03b3 and TBARS and GSH-Px (<jats:italic>p<\/jats:italic> = 0.028, <jats:italic>p<\/jats:italic> = 0.020, respectively) in the OCD group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270823000558_as4\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>For the first time studied in OCD, it has been shown that IFN \u03b3, tryptophan, oxidative stress parameters, and gene variants of CYP1A1 rs4646903 anAhR rs10249788 are shown effective on the KP.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/neu.2023.55","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T05:00:06Z","timestamp":1701147606000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of the effects of oxidative stress, inflammation on the pathway of tryptophan\/kynurenine in 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