{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:37:02Z","timestamp":1790167022370,"version":"4.1.0"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Depression is one of the major mental disorders, which seriously endangers human health, brings a serious burden to patients\u2019 families. In this study, we intended to further explore the antidepressant-like effect and possible molecular mechanisms of Salidroside (SAL). We built corticosterone (CORT)-induced depressive mice model and used behavioural tests to evaluate depression behaviour. To explore the molecular mechanisms of SAL, we employed a variety of methods such as immunofluorescence, western blot, pharmacological interference, etc. The results demonstrated that SAL both at 25 mg\/kg and 50 mg\/kg can reduce immobility time in the tail suspension test (TST). At the same time, SAL treatment could restore the reduced sugar water intake preference in the sucrose preference test (SPT) in CORT-induced depressive mice and reduce the immobility time in TST and forced swimming experiments (FST). In addition, SAL treatment reversed the reduction in the number of Ki-67, BrdU, and NeuN in the hippocampus due to CORT treatment. SAL treatment also restored the expression of SIRT1, PGC-1\u03b1, brain-derived neurotrophic factor (BDNF) and other proteins in the hippocampus. In addition, after blocking SIRT1 signalling with EX527, we found that the treatment with SAL failed to reduce the immobility time in TST and FST, the level of SIRT1 and PGC-1\u03b1 activity were correspondingly downregulated, and the expression of DCX and Ki-67 in the hippocampus failed to be activated. These findings suggested that SAL exerts antidepressant-like effects by promoting hippocampal neurogenesis through the SIRT1\/PGC-1\u03b1 signalling pathway.<\/jats:p>","DOI":"10.1017\/neu.2024.28","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T10:17:17Z","timestamp":1727691437000},"page":"446-456","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1\/PGC-1\u03b1 signalling"],"prefix":"10.1017","volume":"36","author":[{"given":"Shan","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-8369","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"S0924270824000280_ref28","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.cell.2011.10.054","article-title":"SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive","volume":"147","author":"Libert","year":"2011","journal-title":"Cell"},{"key":"S0924270824000280_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14030"},{"key":"S0924270824000280_ref30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13045-019-0724-7","article-title":"CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K\/AKT signaling by inducing Rap1-mediated membrane localization of P110\u03b2 and predicts poor prognosis","volume":"12","author":"Ma","year":"2019","journal-title":"Journal of Hematology and Oncology"},{"key":"S0924270824000280_ref21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition","volume":"22","author":"Keller","year":"2017","journal-title":"Molecular Psychiatry"},{"key":"S0924270824000280_ref10","doi-asserted-by":"crossref","first-page":"812362","DOI":"10.3389\/fphar.2022.812362","article-title":"Salidroside ameliorates depression by suppressing NLRP3-mediated pyroptosis via P2X7\/NF-\u03baB\/NLRP3 signaling pathway","volume":"13","author":"Chai","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"S0924270824000280_ref34","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/nu13030904","article-title":"Saffron extract-induced improvement of depressive-like behavior in mice is associated with modulation of monoaminergic neurotransmission","volume":"13","author":"Monchaux De Oliveira","year":"2021","journal-title":"Nutrients"},{"key":"S0924270824000280_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02648-z"},{"key":"S0924270824000280_ref12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature14659","article-title":"Sparse whole-genome sequencing identifies two loci for major depressive disorder","volume":"523","year":"2015","journal-title":"J, Nature"},{"key":"S0924270824000280_ref11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/03639045.2023.2252062","article-title":"ApoE-modified liposomes encapsulating resveratrol and salidroside alleviate manifestations of alzheimers disease in APP\/PS-1 mice","volume":"49","author":"Chen","year":"2023","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"S0924270824000280_ref39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.phymed.2007.10.003","article-title":"Comparative study of Rhodiola preparations on behavioral despair of rats","volume":"15","author":"Panossian","year":"2008","journal-title":"Phytomedicine"},{"key":"S0924270824000280_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.02.006"},{"key":"S0924270824000280_ref41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41574-019-0174-x","article-title":"Physical activity and muscle-brain crosstalk","volume":"15","author":"Pedersen","year":"2019","journal-title":"Nature Reviews Endocrinology"},{"key":"S0924270824000280_ref42","first-page":"1","article-title":"Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection","volume":"2017","author":"Phillips","year":"2017","journal-title":"Neural Plasticity"},{"key":"S0924270824000280_ref14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s11357-013-9592-1","article-title":"Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi","volume":"36","author":"Du","year":"2014","journal-title":"AGE"},{"key":"S0924270824000280_ref26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00011-012-0545-4","article-title":"Salidroside attenuates inflammatory responses by suppressing nuclear factor-\u03baB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice","volume":"62","author":"Li","year":"2013","journal-title":"Inflammation Research"},{"key":"S0924270824000280_ref35","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00064","article-title":"SIRT1 in the brain\u2014connections with aging-associated disorders and lifespan, frontiers in cellular neuroscience","volume":"9","author":"Ng","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"S0924270824000280_ref40","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/10408398.2017.1400517","article-title":"Resveratrol, human health and winemaking perspectives","volume":"59","author":"Pastor","year":"2019","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"S0924270824000280_ref13","doi-asserted-by":"crossref","first-page":"943321","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"S0924270824000280_ref4","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1038\/s41598-020-60026-1","article-title":"Oleuropein reverses repeated corticosterone-induced depressive-like behavior in mice: evidence of modulating effect on biogenic amines","volume":"10","author":"Badr","year":"2020","journal-title":"Scientific Reports"},{"key":"S0924270824000280_ref23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2010.04.003","article-title":"SIRT1 gene is associated with major depressive disorder in the Japanese population","volume":"126","author":"Kishi","year":"2010","journal-title":"Journal of Affective Disorders"},{"key":"S0924270824000280_ref24","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2023.2253486","article-title":"Sirtuin 1 is a potential therapeutic candidate gene for fetal growth restriction via insulin-like 4","volume":"36","author":"Kojima","year":"2023","journal-title":"The Journal of Maternal-Fetal and Neonatal Medicine"},{"key":"S0924270824000280_ref15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nature Medicine"},{"key":"S0924270824000280_ref5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2174\/1389557519666190903115424","article-title":"Rhodiola and salidroside in the treatment of metabolic disorders","volume":"19","author":"Bai","year":"2019","journal-title":"Mini-Reviews in Medicinal Chemistry"},{"key":"S0924270824000280_ref7","doi-asserted-by":"crossref","first-page":"110540","DOI":"10.1016\/j.cbi.2023.110540","article-title":"Rhodiola rosea and salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection","volume":"380","author":"Calabrese","year":"2023","journal-title":"Chemico-Biological Interactions"},{"key":"S0924270824000280_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0352-1"},{"key":"S0924270824000280_ref27","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/s12906-017-2046-z","article-title":"Inhibition of autophagy enhances synergistic effects of salidroside and anti-tumor agents against colorectal cancer","volume":"17","author":"Li","year":"2017","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"S0924270824000280_ref22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.psyneuen.2018.12.010","article-title":"Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function","volume":"102","author":"Kinlein","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"S0924270824000280_ref8","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s11064-018-2586-8","article-title":"Resveratrol boosts cognitive function by targeting SIRT1","volume":"43","author":"Cao","year":"2018","journal-title":"Neurochemical Research"},{"key":"S0924270824000280_ref29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2022.12.008","article-title":"Salidroside alleviates diabetic cognitive dysfunction via B3galt2\/F3\/Contactin signaling pathway in mice","volume":"512","author":"Lv","year":"2023","journal-title":"Neuroscience"},{"key":"S0924270824000280_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4086"},{"key":"S0924270824000280_ref33","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","article-title":"SIRT1 is essential for normal cognitive function and synaptic plasticity","volume":"30","author":"Michan","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"S0924270824000280_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14282"},{"key":"S0924270824000280_ref38","doi-asserted-by":"publisher","DOI":"10.1177\/117739280700200011"},{"key":"S0924270824000280_ref19","doi-asserted-by":"crossref","first-page":"13866","DOI":"10.1038\/ncomms13866","article-title":"SIRT1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury","volume":"7","author":"Jablonska","year":"2016","journal-title":"Nature Communications"},{"key":"S0924270824000280_ref2","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1016\/j.euroneuro.2020.09.248","article-title":"P.326 efficacy of resveratrol in the treatment of unipolar depression: double-blind randomized placebo-controlled parallel-group study","volume":"40","author":"Aftanas","year":"2020","journal-title":"European Neuropsychopharmacology"},{"key":"S0924270824000280_ref43","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13050719"},{"key":"S0924270824000280_ref44","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200401"},{"key":"S0924270824000280_ref1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.biopsych.2016.01.009","article-title":"Hippocampal sirtuin 1 signaling mediates depression-like behavior","volume":"80","author":"Abe-Higuchi","year":"2016","journal-title":"Biological Psychiatry"},{"key":"S0924270824000280_ref6","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.3390\/molecules27165154","article-title":"Recent overview of resveratrols beneficial effects and its nano-delivery systems","volume":"27","author":"Bohara","year":"2022","journal-title":"Molecules"},{"key":"S0924270824000280_ref47","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.67"},{"key":"S0924270824000280_ref49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11641-8"},{"key":"S0924270824000280_ref51","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01339-1"},{"key":"S0924270824000280_ref53","doi-asserted-by":"crossref","first-page":"16210","DOI":"10.3390\/ijms242216210","article-title":"The role of Sirtuin-1 (SIRT1) in the physiology and pathophysiology of the human placenta","volume":"24","author":"W\u0105troba","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"S0924270824000280_ref55","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fphys.2017.00446","article-title":"Early-life exposure to lead induces cognitive impairment in elder mice targeting SIRT1 phosphorylation and oxidative alterations","volume":"8","author":"Zhang","year":"2017","journal-title":"Frontiers in Physiology"},{"key":"S0924270824000280_ref46","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/acschemneuro.1c00371","article-title":"Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: the involvement of PI3K\/AKT\/NF-\u03baB signaling suppression and CREB\/BDNF signaling restoration in the hippocampus","volume":"12","author":"Sun","year":"2021","journal-title":"ACS Chemical Neuroscience"},{"key":"S0924270824000280_ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0733-3"},{"key":"S0924270824000280_ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1130989"},{"key":"S0924270824000280_ref18","doi-asserted-by":"crossref","first-page":"172797","DOI":"10.1016\/j.ejphar.2019.172797","article-title":"Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK\/NF-\u03baB\/NLRP3 signaling pathway in AGEs-induced HUVECs","volume":"867","author":"Hu","year":"2020","journal-title":"European Journal of Pharmacology"},{"key":"S0924270824000280_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2017.12.007"},{"key":"S0924270824000280_ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.635762"},{"key":"S0924270824000280_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9786-y"},{"key":"S0924270824000280_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.09.065"},{"key":"S0924270824000280_ref52","doi-asserted-by":"crossref","first-page":"e13225","DOI":"10.1016\/j.heliyon.2023.e13225","article-title":"Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating akt\/NF-\u03baB and caspase-3\/GSDME pathways","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"S0924270824000280_ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.812362"},{"key":"S0924270824000280_ref45","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0033291718002556","article-title":"Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy","volume":"49","author":"Ryan","year":"2019","journal-title":"Psychological Medicine"},{"key":"S0924270824000280_ref36","doi-asserted-by":"crossref","first-page":"096032712311695","DOI":"10.1177\/09603271231169520","article-title":"Salidroside attenuates LPS-induced kidney injury through activation of SIRT1\/Nrf2 pathway","volume":"42","author":"Pan","year":"2023","journal-title":"Human and Experimental Toxicology"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270824000280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:04:19Z","timestamp":1742551459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270824000280\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0924270824000280"],"URL":"https:\/\/doi.org\/10.1017\/neu.2024.28","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}