{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:31:55Z","timestamp":1747197115930,"version":"3.40.5"},"reference-count":138,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>From a neuroscientific point of view, one of the unique archetypes of substance use disorders is its road to relapse, in which the reward system plays a crucial role. Studies on the neurobiology of substance use disorders have highlighted the central role of a protein belonging to the Fos family of transcription factors, \u0394FosB. Relying on the roles \u0394FosB plays in the pathophysiology of substance use disorders, we endeavour to present some evidence demonstrating that <jats:italic>N<\/jats:italic>-acetylcysteine, a low-cost and well-tolerated over-the-counter medicine, may influence the downstream pathway of \u0394FosB, thereby serving as a treatment strategy to mitigate the risk of relapse in cases of substance use.<\/jats:p>","DOI":"10.1017\/neu.2024.38","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:54:32Z","timestamp":1729151672000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the potential link between \u0394FosB and <i>N<\/i>-acetylcysteine in craving\/relapse dynamics: can <i>N<\/i>-acetylcysteine stand out as a possible treatment candidate?"],"prefix":"10.1017","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-8702","authenticated-orcid":false,"given":"Shokouh","family":"Arjmand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-5406","authenticated-orcid":false,"given":"Mehran","family":"Ilaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Shafie\u2019ei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro H.","family":"Gobira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Grassi-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-0068","authenticated-orcid":false,"given":"Gregers","family":"Wegener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"S0924270824000383_ref67","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2808-07.2007"},{"key":"S0924270824000383_ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.crstbi.2019.12.001"},{"key":"S0924270824000383_ref126","doi-asserted-by":"publisher","DOI":"10.1021\/cn3000235"},{"key":"S0924270824000383_ref5","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10239"},{"key":"S0924270824000383_ref23","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3492"},{"key":"S0924270824000383_ref132","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.12.021"},{"key":"S0924270824000383_ref51","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200012000-00017"},{"key":"S0924270824000383_ref101","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117730660"},{"key":"S0924270824000383_ref11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2456-10.2011"},{"key":"S0924270824000383_ref109","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1441.030"},{"key":"S0924270824000383_ref25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084353"},{"key":"S0924270824000383_ref81","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1098\/rstb.2008.0067","article-title":"Transcriptional mechanisms of addiction: Role of \u0394FosB","volume":"363","author":"Nestler","year":"2008","journal-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences"},{"key":"S0924270824000383_ref71","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101005","article-title":"N-acetylcysteine (NAC) for methamphetamine dependence: a randomised controlled trial","volume":"38","author":"McKetin","year":"2021","journal-title":"EClinicalMedicine"},{"key":"S0924270824000383_ref104","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.7.8635688"},{"key":"S0924270824000383_ref45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221742110"},{"key":"S0924270824000383_ref85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06176.x"},{"key":"S0924270824000383_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2021.10.002"},{"key":"S0924270824000383_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2021.106816"},{"key":"S0924270824000383_ref79","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012005"},{"key":"S0924270824000383_ref68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179438"},{"key":"S0924270824000383_ref108","first-page":"432","article-title":"How does stress lead to risk of alcohol relapse?","volume":"34","author":"Sinha","year":"2012","journal-title":"Alcohol Research: Current Reviews"},{"key":"S0924270824000383_ref66","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10715760500312305","article-title":"\u03b1-lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-\u03baB and AP-1 transcription factors in human neuroblastoma IMR-32 cells","volume":"40","author":"Mackenzie","year":"2006","journal-title":"Free Radical Research"},{"key":"S0924270824000383_ref99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.08.011"},{"key":"S0924270824000383_ref69","doi-asserted-by":"publisher","DOI":"10.1038\/nn1143"},{"key":"S0924270824000383_ref137","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fnbeh.2014.00297","article-title":"Overexpression of deltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment","volume":"8","author":"Zhang","year":"2014","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"S0924270824000383_ref26","first-page":"33","article-title":"The role of synaptic plasticity in the pathophysiology of cocaine addiction","volume":"37","author":"Daneff","year":"2019","journal-title":"Journal of Young Investigators"},{"key":"S0924270824000383_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115398"},{"key":"S0924270824000383_ref36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160355"},{"key":"S0924270824000383_ref28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2663-16.2018"},{"key":"S0924270824000383_ref125","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1531-08.2008"},{"key":"S0924270824000383_ref8","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1316.041"},{"key":"S0924270824000383_ref10","doi-asserted-by":"publisher","DOI":"10.1038\/35066591"},{"key":"S0924270824000383_ref78","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nn.2250","article-title":"N-acetylcysteine reverses cocaine-induced metaplasticity","volume":"12","author":"Moussawi","year":"2009","journal-title":"Nature Neuroscience"},{"key":"S0924270824000383_ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.173037"},{"key":"S0924270824000383_ref111","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1111\/bph.15456","article-title":"N-acetylcysteine as a new prominent approach for treating psychiatric disorders","volume":"178","author":"Smaga","year":"2021","journal-title":"British Journal of Pharmacology"},{"key":"S0924270824000383_ref21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02488.2003"},{"key":"S0924270824000383_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114089"},{"key":"S0924270824000383_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.04.020"},{"key":"S0924270824000383_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.09.021"},{"key":"S0924270824000383_ref76","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agad044"},{"key":"S0924270824000383_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.040"},{"key":"S0924270824000383_ref113","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.addbeh.2016.08.001","article-title":"Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation","volume":"63","author":"Squeglia","year":"2016","journal-title":"Addictive Behaviors"},{"key":"S0924270824000383_ref119","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3070-06.2006"},{"key":"S0924270824000383_ref41","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00024"},{"key":"S0924270824000383_ref100","doi-asserted-by":"publisher","DOI":"10.1159\/000327682"},{"key":"S0924270824000383_ref6","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2019.21.4\/pkenny"},{"key":"S0924270824000383_ref110","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00283-7"},{"key":"S0924270824000383_ref18","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2021.19.2.282"},{"key":"S0924270824000383_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nature06995"},{"key":"S0924270824000383_ref47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1196\/annals.1316.028","article-title":"Effects of N-acetyl-l-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine","volume":"1025","author":"Hashimoto","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"S0924270824000383_ref7","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011163"},{"key":"S0924270824000383_ref62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1875-13.2013"},{"key":"S0924270824000383_ref115","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040253"},{"key":"S0924270824000383_ref112","doi-asserted-by":"crossref","first-page":"112491","DOI":"10.3389\/fnana.2014.00110","article-title":"The \u201caddicted\u201d spine","volume":"8","author":"Spiga","year":"2014","journal-title":"Frontiers in Neuroanatomy"},{"key":"S0924270824000383_ref121","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4970-05.2006"},{"key":"S0924270824000383_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.09.019"},{"key":"S0924270824000383_ref20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-24-08965.2000"},{"key":"S0924270824000383_ref19","doi-asserted-by":"crossref","first-page":"100295","DOI":"10.1016\/j.bpsgos.2024.100295","article-title":"Fundamental sex differences in cocaine-induced plasticity of dopamine D1 receptor-and D2 receptor-expressing medium spiny neurons in the mouse nucleus accumbens shell","volume":"4","author":"Chapp","year":"2024","journal-title":"Biological Psychiatry Global Open Science"},{"key":"S0924270824000383_ref84","doi-asserted-by":"crossref","first-page":"11042","DOI":"10.1073\/pnas.191352698","article-title":"\u0394FosB: A sustained molecular switch for addiction","volume":"98","author":"Nestler","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"S0924270824000383_ref32","first-page":"1","article-title":"Effects of dietary curcumin or N-acetylcysteine on NF-\u03baB activity and contractile performance in ambulatory and unloaded murine soleus","volume":"2","author":"Farid","year":"2005","journal-title":"Nutrition and Metabolism"},{"key":"S0924270824000383_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12620"},{"key":"S0924270824000383_ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.03.023"},{"key":"S0924270824000383_ref93","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12127"},{"key":"S0924270824000383_ref124","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.046"},{"key":"S0924270824000383_ref129","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_27"},{"key":"S0924270824000383_ref55","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022110721"},{"key":"S0924270824000383_ref114","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.12.005"},{"key":"S0924270824000383_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12273"},{"key":"S0924270824000383_ref63","doi-asserted-by":"crossref","first-page":"18381","DOI":"10.1523\/JNEUROSCI.1875-13.2013","article-title":"\u0394FosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli","volume":"33","author":"Lobo","year":"2013","journal-title":"Journal of Neuroscience"},{"key":"S0924270824000383_ref105","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4415"},{"key":"S0924270824000383_ref107","doi-asserted-by":"crossref","first-page":"518 4","DOI":"10.1096\/fasebj.30.1_supplement.518.4","article-title":"Role of hippocampal neurogenesis in drug addiction","volume":"30","author":"Silva","year":"2016","journal-title":"The FASEB Journal"},{"key":"S0924270824000383_ref43","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12010055"},{"volume-title":"Cureus.comAD harlivasari, AD Susanto, FF Taufik, TT ginting, ADA Susanto sr, FF Taufik, T gintingCureus","year":"2024, undefined, 2024","author":"Harlivasari","key":"S0924270824000383_ref46"},{"key":"S0924270824000383_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.08.002"},{"key":"S0924270824000383_ref123","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2551"},{"key":"S0924270824000383_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12798"},{"key":"S0924270824000383_ref127","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.017"},{"key":"S0924270824000383_ref52","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3354"},{"key":"S0924270824000383_ref135","doi-asserted-by":"crossref","first-page":"e77791","DOI":"10.7554\/eLife.77791","article-title":"Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort","volume":"11","author":"Zalachoras","year":"2022","journal-title":"Elife"},{"key":"S0924270824000383_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108815"},{"key":"S0924270824000383_ref128","doi-asserted-by":"crossref","first-page":"109781","DOI":"10.1016\/j.pnpbp.2019.109781","article-title":"Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-\u0394FosB signaling in the mouse nucleus accumbens","volume":"97","author":"Wen","year":"2020","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"S0924270824000383_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104674"},{"key":"S0924270824000383_ref122","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1381-12.2012"},{"key":"S0924270824000383_ref138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-021-00892-6","article-title":"Progress on the roles of MEF2C in neuropsychiatric diseases","volume":"15","author":"Zhang","year":"2022","journal-title":"Molecular Brain"},{"key":"S0924270824000383_ref42","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08411"},{"key":"S0924270824000383_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.06.017"},{"key":"S0924270824000383_ref96","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113477"},{"key":"S0924270824000383_ref17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnbeh.2016.00173","article-title":"Stress-induced locomotor sensitization to amphetamine in adult, but not in adolescent rats, is associated with increased expression of \u0394FosB in the nucleus accumbens","volume":"10","author":"Carneiro De Oliveira","year":"2016","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"S0924270824000383_ref120","doi-asserted-by":"publisher","DOI":"10.1038\/srep13396"},{"key":"S0924270824000383_ref136","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12462"},{"key":"S0924270824000383_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.01.001"},{"key":"S0924270824000383_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05575.x"},{"key":"S0924270824000383_ref130","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0015-19.2019"},{"key":"S0924270824000383_ref80","doi-asserted-by":"crossref","first-page":"136","DOI":"10.9758\/cpn.2012.10.3.136","article-title":"Transcriptional mechanisms of drug addiction","volume":"10","author":"Nestler","year":"2012","journal-title":"Clinical Psychopharmacology and Neuroscience"},{"key":"S0924270824000383_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.07.008"},{"key":"S0924270824000383_ref94","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1523\/JNEUROSCI.17-21-08491.1997","article-title":"Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine","volume":"17","author":"Robinson","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"S0924270824000383_ref106","doi-asserted-by":"publisher","DOI":"10.3390\/cells12141812"},{"key":"S0924270824000383_ref83","doi-asserted-by":"publisher","DOI":"10.1080\/105504901750532094"},{"key":"S0924270824000383_ref60","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12521"},{"key":"S0924270824000383_ref118","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01163-5"},{"key":"S0924270824000383_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1171"},{"key":"S0924270824000383_ref77","first-page":"28","article-title":"The efficacy of N-acetylcysteine in the treatment of methamphetamine dependence: a double-blind controlled, crossover study","volume":"18","author":"Mousavi","year":"2015","journal-title":"Archives of Iranian Medicine"},{"key":"S0924270824000383_ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06907.x"},{"key":"S0924270824000383_ref82","doi-asserted-by":"publisher","DOI":"10.1038\/nn1578"},{"key":"S0924270824000383_ref103","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6105.1000297"},{"key":"S0924270824000383_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812202-0.00003-8"},{"key":"S0924270824000383_ref61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511244103"},{"key":"S0924270824000383_ref58","doi-asserted-by":"publisher","DOI":"10.1080\/10550490500419169"},{"key":"S0924270824000383_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00907-3"},{"key":"S0924270824000383_ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.07.009"},{"key":"S0924270824000383_ref3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1471-4159.2001.00563.x","article-title":"Induction of nuclear factor-\u03baB in nucleus accumbens by chronic cocaine administration","volume":"79","author":"Ang","year":"2008","journal-title":"Journal of Neurochemistry"},{"key":"S0924270824000383_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2003.08.004"},{"key":"S0924270824000383_ref131","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12900"},{"key":"S0924270824000383_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.226"},{"key":"S0924270824000383_ref91","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neuron.2008.06.020","article-title":"Cocaine regulates MEF2 to control synaptic and behavioral plasticity","volume":"59","author":"Pulipparacharuvil","year":"2008","journal-title":"Neuron"},{"key":"S0924270824000383_ref97","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00341"},{"key":"S0924270824000383_ref98","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/WNR.0000000000001400","article-title":"Anandamide and sucralose change \u0394FosB expression in the reward system","volume":"31","author":"Salaya-Velazquez","year":"2020","journal-title":"Neuroreport"},{"key":"S0924270824000383_ref48","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4388-5"},{"key":"S0924270824000383_ref89","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20500"},{"key":"S0924270824000383_ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.10.018"},{"key":"S0924270824000383_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.069"},{"key":"S0924270824000383_ref50","doi-asserted-by":"publisher","DOI":"10.1038\/45790"},{"key":"S0924270824000383_ref72","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2018.83.037663"},{"key":"S0924270824000383_ref33","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1510\/icvts.2006.130765","article-title":"Impact of antioxidative treatment on nuclear factor kappa-B regulation during myocardial ischemia-reperfusion","volume":"5","author":"Fischer","year":"2006","journal-title":"Interactive CardioVascular and Thoracic Surgery"},{"key":"S0924270824000383_ref86","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01464-2"},{"key":"S0924270824000383_ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.01.002"},{"key":"S0924270824000383_ref90","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1179\/1351000215Y.0000000004","article-title":"N-acetylcysteine for therapy-resistant tobacco use disorder: a pilot study","volume":"20","author":"Prado","year":"2015","journal-title":"Redox Report"},{"key":"S0924270824000383_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24736"},{"key":"S0924270824000383_ref57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2013.12034.x"},{"key":"S0924270824000383_ref88","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2542-04.2004"},{"key":"S0924270824000383_ref95","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5192-12.2013"},{"key":"S0924270824000383_ref117","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-022-00922-x"},{"key":"S0924270824000383_ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.03.010"},{"key":"S0924270824000383_ref134","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nn1636","article-title":"An essential role for \u0394FosB in the nucleus accumbens in morphine action","volume":"9","author":"Zachariou","year":"2006","journal-title":"Nature Neuroscience"},{"key":"S0924270824000383_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.018"},{"key":"S0924270824000383_ref27","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100057"},{"key":"S0924270824000383_ref65","first-page":"177","article-title":"Animal models of substance abuse and addiction: implications for science, animal welfare, and society","volume":"60","author":"Lynch","year":"2010","journal-title":"Comparative Medicine"},{"key":"S0924270824000383_ref74","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1251580"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270824000383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T12:23:58Z","timestamp":1742819038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270824000383\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":138,"alternative-id":["S0924270824000383"],"URL":"https:\/\/doi.org\/10.1017\/neu.2024.38","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"type":"print","value":"0924-2708"},{"type":"electronic","value":"1601-5215"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e31"}}