{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:27:28Z","timestamp":1789648048948,"version":"4.0.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924270824000462_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Phelan-McDermid syndrome is a rare genetic disorder characterised by various neurodevelopmental, medical, and psychiatric issues. Although bipolar disorder-like presentations and catatonia are particularly common, psychosis has also been reported but is less well described. As such, this systematic review sought to characterise the phenomenology of psychosis in Phelan-McDermid syndrome, clarify the association of psychotic symptoms with other neuropsychiatric features of the disorder, and describe antipsychotic treatment response.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000462_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>A literature search was completed in July 2024 using PubMed and Scopus. Only English-language articles that reported the occurrence of psychotic symptoms in Phelan-McDermid syndrome were eligible for inclusion. 18 articles describing 35 individuals were included in the main analyses. Three additional articles of relevance are discussed separately, as they either provided limited clinical information or did not present data in a patient-specific manner.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000462_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>The average age of psychosis onset was \u223c17 years, and 65% of individuals developed symptoms at or before age 15. \u223c69% of individuals also experienced catatonia, \u223c81% experienced mood symptoms, and 50% experienced both. Visual hallucinations were the most commonly reported psychotic symptom. Where reported, \u223c76% of individuals exhibited at least a partial and\/or temporary response to antipsychotic therapy.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000462_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>Psychotic presentations in Phelan-McDermid syndrome may qualitatively differ from schizophrenia. Although numerous antipsychotics may be efficacious in the treatment of Phelan-McDermid syndrome-associated psychosis, this review most importantly highlights the paucity of available high-quality evidence to guide treatment decisions in this respect, and as such indicates the need for more reports to be published.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/neu.2024.46","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T07:37:10Z","timestamp":1732088230000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Phelan-McDermid syndrome-associated psychosis: a systematic review"],"prefix":"10.1017","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-1173","authenticated-orcid":false,"given":"Mark 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Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e15"}}