{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:52:41Z","timestamp":1777665161239,"version":"3.51.4"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924270824000498_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>Mechanisms of sleep disorders in fibromyalgia (FM) patients, such as insomnia, early morning awakenings and poor quality sleep, have not yet been proven and no consistent and effective treatment is yet available. The aim of this study was to investigate the pineal gland volume and the relationship between total fibre count, total fibre volume and total fibre length of the spinoreticular tract involved in regulation of sleep and wakefulness in terms of the mechanism of sleep disturbance.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000498_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>This study included only female cases, 31 with fibromyalgia and 31 controls. Pittsburgh Sleep Quality Index was used to assess sleep quality. Tractography of targeted pathway from brain diffusion MR images was calculated in Diffusion Studio Imaging (DSI) Studio programme and the volume of the pineal gland was calculated in ITK-SNAP programme.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000498_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>The mean volume of the pineal gland was higher in control group (218.84 \u00b1 64.45 mm<jats:sup>3<\/jats:sup>) than in fibromyalgia group (174.77 \u00b1 48.65 mm<jats:sup>3<\/jats:sup>), which was statistically significant (<jats:italic>p<\/jats:italic> = 0.004). However, there was no statistically significant difference between two groups in total spinoreticular tract (TSRT), total volume (TSRTV), TSRT fractional anisotropy, TSRT mean diffusion, TSRT axial diffusion and TSRT radial diffusion of spinoreticular tract, which is involved in the regulation of sleep and wakefulness (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000498_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>In conclusion, it is thought that the endocrine system may be more related to sleep disturbance in individuals with FM than central nervous system. Therefore, we believe that it may be more appropriate to work on the endocrine system rather than neural system in the treatment of sleep disturbance in patients with FM.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/neu.2024.49","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T06:33:31Z","timestamp":1731306811000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of the relationship of sleep disorder occurring in fibromyalgia with central nervous system and pineal gland volume"],"prefix":"10.1017","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9377-6187","authenticated-orcid":false,"given":"Fatih","family":"\u00c7i\u00e7ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-5320","authenticated-orcid":false,"given":"\u0130lyas","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-4058","authenticated-orcid":false,"given":"Turgut","family":"Seber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-8568","authenticated-orcid":false,"given":"Fatma G\u00fcl","family":"\u00dclk\u00fc Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-5273","authenticated-orcid":false,"given":"Ali T\u00fcrker","family":"\u00c7ift\u00e7i","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"S0924270824000498_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.22"},{"key":"S0924270824000498_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000002300"},{"key":"S0924270824000498_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0330-8"},{"key":"S0924270824000498_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00051"},{"key":"S0924270824000498_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"S0924270824000498_ref1","first-page":"107","article-title":"The validity and reliability of the Pittsburgh Sleep Quality Index","volume":"7","author":"Agargun","year":"1996","journal-title":"Turkish Journal of Psychiatry"},{"key":"S0924270824000498_ref10","doi-asserted-by":"publisher","DOI":"10.58600\/eurjther-28-4-0104"},{"key":"S0924270824000498_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2020.01.002"},{"key":"S0924270824000498_ref11","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2023.9668"},{"key":"S0924270824000498_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2021.35"},{"key":"S0924270824000498_ref7","first-page":"1","volume-title":"Fibromyalgia: Clinical Guidelines and Treatments","author":"Chen","year":"2015"},{"key":"S0924270824000498_ref6","first-page":"331","article-title":"Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)","volume":"14","author":"Buysse","year":"1991","journal-title":"Sleep"},{"key":"S0924270824000498_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0213-3"},{"key":"S0924270824000498_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00506-w"},{"key":"S0924270824000498_ref19","first-page":"227","article-title":"Fibromyalgia and sleep","volume":"25","author":"Spaeth","year":"2011","journal-title":"Clinical Rheumatology"},{"key":"S0924270824000498_ref9","doi-asserted-by":"publisher","DOI":"10.13004\/kjnt.2023.19.e43"},{"key":"S0924270824000498_ref2","unstructured":"Arendt, J and Aulinas, A (2022) Physiology of the pineal gland and melatonin. Endotext. https:\/\/europepmc.org\/article\/NBK\/nbk550972. Accessed 17 April 2024."},{"key":"S0924270824000498_ref12","volume-title":"Barr\u2019s the Human Nervous System: An Anatomical Viewpoint","author":"Kiernan","year":"2009"},{"key":"S0924270824000498_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12125"},{"key":"S0924270824000498_ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00450"},{"key":"S0924270824000498_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-022-07452-z"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270824000498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T23:48:35Z","timestamp":1741823315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270824000498\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":21,"alternative-id":["S0924270824000498"],"URL":"https:\/\/doi.org\/10.1017\/neu.2024.49","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e17"}}