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While inflammation may promote telomere shortening, few studies have investigated the association between telomere length (TL) and markers of immune activation and inflammation in severe mental disorders.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000620_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>Leucocyte TL defined as telomere template\/amount of single-copy gene template (T\/S ratio), was determined in participants with SCZ (<jats:italic>N<\/jats:italic> = 301) or BD (<jats:italic>N<\/jats:italic> = 211) and a healthy control group (HC, <jats:italic>N<\/jats:italic> = 378). TL was analysed with linear regressions for associations with levels of 12 immune markers linked to SCZ or BD. Adjustments were made for a broad range of potential confounding variables. TL was measured by quantitative polymerase chain reaction (qPCR) and the immune markers were measured by enzyme immunoassays.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000620_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>A positive association between levels of soluble tumour necrosis factor receptor 1A (sTNF-R1) and TL in SCZ (<jats:italic>\u03b2<\/jats:italic> = 0.191, <jats:italic>p<\/jats:italic> = 0.012) was observed. Plasma levels of the other immune markers were not significantly associated with TL in the BD, SCZ or HC groups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270824000620_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>There was limited evidence of association between immune markers and TL in SCZ and BD. 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