{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:41:19Z","timestamp":1772289679252,"version":"3.50.1"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270824000097_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sialorrhea is a common and uncomfortable adverse effect of clozapine, and its severity varies between patients. The aim of the study was to select broadly genes related to the regulation of salivation and study associations between sialorrhea and dry mouth and polymorphisms in the selected genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270824000097_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study population consists of 237 clozapine-treated patients, of which 172 were genotyped. Associations between sialorrhea and dry mouth with age, sex, BMI, smoking, clozapine dose, clozapine and norclozapine serum levels, and other comedication were studied. Genetic associations were analyzed with linear and logistic regression models explaining sialorrhea and dry mouth with each SNP added separately to the model as coefficients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270824000097_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Clozapine dose, clozapine or norclozapine concentration and their ratio were not associated with sialorrhea or dryness of mouth. Valproate use (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) and use of other antipsychotics (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015) combined with clozapine were associated with excessive salivation. No associations were found between studied polymorphisms and sialorrhea. In analyses explaining dry mouth with logistic regression with age and sex as coefficients, two proxy-SNPs were associated with dry mouth: epidermal growth factor receptor 4\n                      <jats:italic>(ERBB4)<\/jats:italic>\n                      rs3942465 (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.025) and tachykinin receptor 1\n                      <jats:italic>(TACR1)<\/jats:italic>\n                      rs58933792 (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270824000097_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Use of valproate or antipsychotic polypharmacy may increase the risk of sialorrhea. Genetic variations in\n                      <jats:italic>ERBB4<\/jats:italic>\n                      and\n                      <jats:italic>TACR1<\/jats:italic>\n                      might contribute to experienced dryness of mouth among patients treated with clozapine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2024.9","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:41:00Z","timestamp":1713418860000},"page":"218-223","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphisms in\n                    <i>ERBB4<\/i>\n                    and\n                    <i>TACR1<\/i>\n                    associated with dry mouth in clozapine-treated patients"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6145-1745","authenticated-orcid":false,"given":"Hanna","family":"Puolakka","sequence":"first","affiliation":[{"name":"Tampere University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anssi","family":"Solismaa","sequence":"additional","affiliation":[{"name":"Tampere University"},{"name":"The Pirkanmaa Wellbeing Services County"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo-Pekka","family":"Lyytik\u00e4inen","sequence":"additional","affiliation":[{"name":"Tampere University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Viikki","sequence":"additional","affiliation":[{"name":"Tampere University"},{"name":"The Wellbeing Services County of Ostrobothnia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niko","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Tampere 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