{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:17:12Z","timestamp":1790421432548,"version":"4.1.0"},"reference-count":84,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270825100343_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS) is highly prevalent among adults and is frequently accompanied by depressive symptoms. While high-sensitivity C-reactive protein (hsCRP) has been proposed as a potential indicator of depression, existing evidence remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100343_as2\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to determine whether increased serum hsCRP or other immune-metabolic biomarkers are associated with depressive symptoms in drug-na\u00efve individuals with obesity and MetS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100343_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 88 drug-na\u00efve patients with obesity and MetS but without coronary artery disease were enrolled and serum levels of neuro-immune and metabolic biomarkers were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100343_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In MetS, the severity of depression, as assessed using the von Zerssen Depression Rating (VZDR) scale was significantly associated with interleukin (IL)-6, leukocyte numbers, triglyceride \u00d7 glucose (Tyg) index, low-density lipoprotein cholesterol, Apolipoprotein B (all positively) and mean platelet volume (MPV), visfatin and adiponectin (all negatively). There were no significant associations between hsCRP and severity of depression. In MetS patients, hsCRP is strongly associated with increased leukocyte numbers, alkaline phosphatase, \u03b3-glutamyl transferase, uric acid, platelet numbers and MPV, thereby shaping a distinct subtype of MetS, which is not related to depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100343_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings indicate that depressive symptoms in MetS patients are associated with immune\u2013metabolic biomarkers indicating immune activation, atherogenicity and insulin resistance, but not with hsCRP. The reason is that hsCRP in MetS is a biomarker of a specific MetS subtype that is characterized by megakaryopoiesis, hepatocyte activation, and uric acid production, which were not associated with depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2025.10034","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T07:11:24Z","timestamp":1756192284000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["C-reactive protein is not a biomarker of depression severity in drug-na\u00efve obese patients with metabolic syndrome"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-6731","authenticated-orcid":false,"given":"Abbas F.","family":"Almulla","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Electronic Science and Technology of China"},{"name":"Chinese Academy of Medical Sciences"},{"name":"The Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spas","family":"Kitov","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"St. George University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Deneva","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Florance","family":"Kitova","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila","family":"Kitova","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"St. George University Hospital"},{"name":"Medical University of Plovdiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Stoyanova","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"Medical University of Plovdiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-3680","authenticated-orcid":false,"given":"Drozdstoy","family":"Stoyanov","sequence":"additional","affiliation":[{"name":"Medical University of Plovdiv"},{"name":"Medical University of Plovdiv"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-871X","authenticated-orcid":false,"given":"Michael","family":"Maes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04qr3zq92","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Electronic Science and Technology of China"},{"name":"Chinese Academy of Medical Sciences"},{"name":"Medical University of Plovdiv"},{"name":"Medical University of Plovdiv"},{"name":"Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"S0924270825100343_ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1358"},{"key":"S0924270825100343_ref81","volume-title":"Waist circumference and waist-hip ratio : report of a WHO expert consultation, Geneva, 8-11 December 2008","year":"2011"},{"key":"S0924270825100343_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.223768"},{"key":"S0924270825100343_ref48","doi-asserted-by":"publisher","DOI":"10.1101\/2025.03.02.25323183"},{"key":"S0924270825100343_ref47","first-page":"380","article-title":"Increased insulin resistance is associated with depressive symptoms due to long COVID","volume":"45","author":"Maes","year":"2023","journal-title":"Brazilian Journal of Psychiatry"},{"key":"S0924270825100343_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(95)00028-L"},{"key":"S0924270825100343_ref82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.06.003"},{"key":"S0924270825100343_ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100871"},{"key":"S0924270825100343_ref79","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2025.1540721"},{"key":"S0924270825100343_ref9","unstructured":"Anderson, G (2025) Reframing polymyalgia pathoetiology, pathophysiology and treatment: role of aging-linked alterations in night-time dampening and resetting by melatonin and cortisol in modulation of local melatonin production via the STAT3 interface with NF-kB dimer composition, with future research and treatment implications. 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