{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:07:46Z","timestamp":1785409666985,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270825100367_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Autoimmune psychosis (AP) and other autoimmune psychiatric syndromes (APS) are associated with central nervous system antibodies. This study investigated related magnetic resonance spectroscopic imaging (MRSI) signatures and their correlations with electroencephalography (EEG), cerebrospinal fluid (CSF), and psychometric\/neuropsychological measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100367_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-eight adults with suspected antibody-positive AP spectrum syndromes were compared with 28 matched healthy controls. Inclusion in the patient group was based on the APS concept, resulting in a heterogeneous group with uniform autoimmunity. MRSI was performed using a spiral-encoded Mescher-Garwood localised adiabatic selective refocusing 3D-MRSI sequence. Glutamate+glutamine (Glx), gamma-aminobutyric acid (GABA), total N-acetylaspartate (tNAA), and total creatine (tCr) were reported as ratios to tNAA and\/or tCr. EEG was analysed for intermittent rhythmic delta\/theta activity (IRDA\/IRTA) using independent component analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100367_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No significant differences in Glx, GABA, tNAA, or tCr ratios were observed between patients and controls. Correlation analyses in patients showed a trend for a negative association of the IRDA\/IRTA rate before hyperventilation with the GABA\/tCr ratio in both hippocampi and with the GABA\/tNAA ratio in the left hippocampus and Glx\/tCr ratio in the right putamen and pallidum. Significant positive correlations were observed between inflammatory CSF markers (white blood cell count and IgG Index) and GABA\/tCr and GABA\/tNAA ratios in the left caudate nucleus and right isthmus cingulate and thalamus, as well as between negative symptoms in PANSS and higher GABA\/tCr ratios in the right putamen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270825100367_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>No group differences were identified; however, correlations suggest a link between neuroinflammatory CSF markers and negative symptoms with GABAergic signalling in patients. Multimodal diagnostic approaches may provide a better understanding of the link between neuroinflammation, neurochemistry, and EEG slowing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2025.10036","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:04:55Z","timestamp":1758089095000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["MR spectroscopic imaging and its association with EEG, CSF, and psychometric\/neuropsychological findings in patients with suspected autoimmune psychosis spectrum syndromes"],"prefix":"10.1017","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7322-1195","authenticated-orcid":false,"given":"Dominique","family":"Endres","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Matteit","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"von Zedtwitz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Feige","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schlump","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Reisert","sequence":"additional","affiliation":[{"name":"University of Freiburg"},{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Nickel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Runge","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Domschke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"},{"name":"German Center for Mental Health (DZPG)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Perlov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"},{"name":"Hospital St. Urban"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rau","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Pr\u00fcss","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lange","sequence":"additional","affiliation":[{"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger Tebartz","family":"van Elst","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Maier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03vzbgh69","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Freiburg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,17]]},"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270825100367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:31:00Z","timestamp":1761121860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270825100367\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":0,"alternative-id":["S0924270825100367"],"URL":"https:\/\/doi.org\/10.1017\/neu.2025.10036","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e88"}}