{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:05:38Z","timestamp":1784001938068,"version":"3.55.0"},"reference-count":80,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"unspecified","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0924270825000158_as1\">\n\t    <jats:title>Objectives:<\/jats:title>\n\t    <jats:p>Dementia with Lewy bodies (DLB) and Parkinson\u2019s disease dementia (PDD) are collectively called as Lewy body dementia (LBD). Despite the urgent clinical need, there is no reliable protein biomarker for LBD. Hence, we conducted the first comprehensive systematic review of all Differentially Abundant Proteins (DAP) in all tissues from people with LBD for advancing our understanding of LBD molecular pathology that is essential for facilitating discovery of novel diagnostic biomarkers and therapeutic targets for LBD.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270825000158_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>We identified eligible studies by comprehensively searching five databases and grey literature (PROSPERO protocol:CRD42020218889). We completed quality assessment and extracted relevant data. We completed narrative synthesis and appropriate meta-analyses. We analysed functional implications of all reported DAP using <jats:italic>DAVID<\/jats:italic> tools.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270825000158_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>We screened 11,006 articles and identified 193 eligible studies. 305 DAP were reported and 16 were replicated in DLB. 37 DAP were reported and three were replicated in PDD. Our meta-analyses confirmed six DAP (TAU, SYUA, NFL, CHI3L1, GFAP, CLAT) in DLB, and three DAP (TAU, SYUA, NFL) in PDD. There was no replicated blood-based DAP in DLB or PDD. The reported DAP may contribute to LBD pathology by impacting misfolded protein clearance, dopamine neurotransmission, apoptosis, neuroinflammation, synaptic plasticity and extracellular vesicles.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0924270825000158_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>Our meta-analyses confirmed significantly lower CSF TAU levels in DLB and CSF SYUA levels in PDD, when compared to Alzheimer\u2019s disease. Our findings indicate promising diagnostic biomarkers for LBD and may help prioritising molecular pathways for therapeutic target discovery. We highlight ten future research priorities based on our findings.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/neu.2025.15","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T02:39:50Z","timestamp":1743043190000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Systematic review of differentially abundant proteins in people with Lewy body dementia"],"prefix":"10.1017","volume":"37","author":[{"given":"Laura M.","family":"Farr","sequence":"first","affiliation":[{"name":"University of Nottingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Nottinghamshire Healthcare NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel M.","family":"Brinda","sequence":"additional","affiliation":[{"name":"Nottinghamshire Healthcare NHS Foundation 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Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e59"}}