{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:17:21Z","timestamp":1785406641040,"version":"3.56.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"unspecified","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270826100660_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Investigating metabolic differences between pre-pubertal Flinders sensitive (FSL) and resistant (FRL) line rats and determine the impact of early-life adversity on these differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100660_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Untargeted metabolomic profiling of whole-brain tissue from postnatal day 25 Flinders line rats, exposed to maternal separation with early weaning (MSEW), or not, was done by using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100660_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Irrespective of MSEW, FSL rats had higher urea and lower glutamine, norvaline and valine concentrations than age-matched FRL controls. Across strains, MSEW reduced gamma-aminobutyric acid (GABA), glutamate, glutamine, lactate, phenylalanine, norvaline and valine concentrations, whist elevating 2-keto-3-methylbutyric acid, glycerophosphate, and urea. This effect was most pronounced in FRL rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100660_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pre-pubertal FSL rats displayed distinct metabolic signatures associated with altered energy and amino acid metabolism. Early-life stress further disrupts these pathways, highlighting key metabolites as potential targets in the expansion of the biological constructs underlying the pre-pubertal FSL\/FRL model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2026.10066","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:51:30Z","timestamp":1772707890000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Early-life adversity induces metabolic alterations in a rodent model of depression: a differential stress response perspective"],"prefix":"10.1017","volume":"38","author":[{"given":"Dani\u00ebl J.","family":"van Rensburg","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010f1sq29","id-type":"ROR","asserted-by":"publisher"}],"name":"North-West University (NWU)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zander","family":"Lindeque","sequence":"additional","affiliation":[{"name":"North-West University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh Jade","family":"Whitney","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010f1sq29","id-type":"ROR","asserted-by":"publisher"}],"name":"North-West University (NWU)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9711","authenticated-orcid":false,"given":"Stephan F.","family":"Steyn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/010f1sq29","id-type":"ROR","asserted-by":"publisher"}],"name":"North-West University (NWU)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"S0924270826100660_ref2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0193-22.2022"},{"key":"S0924270826100660_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001949"},{"key":"S0924270826100660_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2023.37"},{"key":"S0924270826100660_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114321"},{"key":"S0924270826100660_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9594-3"},{"key":"S0924270826100660_ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-016-0139-z"},{"key":"S0924270826100660_ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00386"},{"key":"S0924270826100660_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05696-5"},{"key":"S0924270826100660_ref14","volume-title":"Alzheimer\u2019s Disease","author":"Polis","year":"2019"},{"key":"S0924270826100660_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.70058"},{"key":"S0924270826100660_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2007.06.007"},{"key":"S0924270826100660_ref12","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005397"},{"key":"S0924270826100660_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.05.039"},{"key":"S0924270826100660_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.04.023"},{"key":"S0924270826100660_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.12.043"},{"key":"S0924270826100660_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2024.61"},{"key":"S0924270826100660_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbad169"},{"key":"S0924270826100660_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1003"},{"key":"S0924270826100660_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.10.002"},{"key":"S0924270826100660_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.02.001"},{"key":"S0924270826100660_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00086-X"},{"key":"S0924270826100660_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-012-0459-8"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270826100660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:54:35Z","timestamp":1784271275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270826100660\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":22,"alternative-id":["S0924270826100660"],"URL":"https:\/\/doi.org\/10.1017\/neu.2026.10066","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial licence (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e18"}}