{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:07:25Z","timestamp":1793340445336,"version":"4.5.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270826100738_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>There is a need for deeper understanding of neurological and psychological aspects of paedophilic disorder (PeD) to improve management of the disorder and thereby prevent child sexual abuse (CSA). Functional magnetic resonance imaging (fMRI) measures have been suggested as imaging biomarkers that may contribute towards this goal. A previous study using degarelix, a testosterone suppressing drug, showed promising results in decreasing the risk of committing CSA among individuals with PeD. In this study, we evaluate functional connectivity (FC) related to PeD and degarelix treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100738_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We used independent component analysis on resting state (rs)fMRI data acquired at baseline as well as two and ten weeks after injection of degarelix (or placebo) to evaluate FC alterations related to PeD and the degarelix treatment effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100738_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>FC was altered in relation to several resting state networks in individuals with PeD compared to healthy controls at baseline. At follow-up time points, however, group comparisons were inconclusive and did after FDR correction not render statistically significant FC alterations when comparing patients to controls or related to degarelix treatment, CSA dynamic risk scores or comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100738_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found FC alterations in PeD compared to healthy controls at baseline, however, no consistent, treatment specific FC signature of degarelix was demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2026.10073","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:41:26Z","timestamp":1775022086000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Resting state functional connectivity in paedophilic disorder and degarelix treatment"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4467-2892","authenticated-orcid":false,"given":"Linn\u00e9a","family":"Andersson","sequence":"first","affiliation":[{"name":"Sahlgrenska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mannfolk","sequence":"additional","affiliation":[{"name":"Karolinska Institutet & Stockholm Health Care Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-2353","authenticated-orcid":false,"given":"Maria","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital"},{"name":"Sahlgrenska Academy, University of Gothenburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Liberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet & Stockholm Health Care Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Rahm","sequence":"additional","affiliation":[{"name":"Karolinska Institutet & Stockholm Health Care Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Maria","family":"Bj\u00f6rkman-Burtscher","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01tm6cn81","id-type":"ROR","asserted-by":"publisher"}],"name":"Sahlgrenska Academy, University of Gothenburg"},{"id":[{"id":"https:\/\/ror.org\/04vgqjj36","id-type":"ROR","asserted-by":"publisher"}],"name":"Sahlgrenska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"S0924270826100738_ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.571775"},{"key":"S0924270826100738_ref26","doi-asserted-by":"publisher","DOI":"10.1177\/1077559511403920"},{"key":"S0924270826100738_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.01.035"},{"key":"S0924270826100738_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02611-6"},{"key":"S0924270826100738_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-1"},{"key":"S0924270826100738_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12819"},{"key":"S0924270826100738_ref18","first-page":"773","article-title":"Drawing the line on virtual child pornography: Bringing the law in line with the research evidence","volume":"31","author":"Malamuth","year":"2007","journal-title":"N.Y.U. 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Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e35"}}