{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:34:17Z","timestamp":1785418457597,"version":"3.56.0"},"reference-count":117,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"unspecified","delay-in-days":127,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270826100854_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Dementia is a group of symptoms, characterised by a loss of cognition that interferes with everyday tasks, difficulty focusing, planning, problem solving, and behavioural changes, such as apathy, anxiety, or depression. The leading cause of dementia is Alzheimer\u2019s disease, but vascular dementia or mild cognitive impairment are also frequently occurring. There are six drugs legislated in Europe for use in the treatment of dementia. There are unmet clinical needs to find more effective, better tolerated or complementary therapeutic options. The aim of this study is to comprehensively analyse the results of clinical trials and other human studies regarding the efficacy and safety of herbal interventions used in patients with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100854_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We enrolled a total of 48 studies for this systematic review, of which 27 were included into the statistical analysis of effect size (Cohen\u2019s d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100854_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found significant improvements mainly after administration of Ginkgo biloba, Crocus sativus, Salvia officinalis, and Melissa officinalis. It should be emphasised that some herbs and herbal formulations demonstrated efficacy comparable to that of donepezil, a widely used and approved medication, suggesting potential for phytopharmaceutical therapies as complementary approaches. In some studies, the observed effects were similar to those reported for conventional treatments, indicating promising directions for further research in Alzheimer\u2019s disease and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100854_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In light of the evidence, phytopharmaceuticals have a promising role as a co-therapeutic option or alternative for patients with dementia who do not tolerate or have contraindications to standard medications. However, further research is necessary to translate these initial promising results into clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2026.10085","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:21:12Z","timestamp":1778232072000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["A comprehensive systematic review of human trials investigating herbal treatments for Alzheimer\u2019s disease and dementia"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9329-6317","authenticated-orcid":false,"given":"Katarzyna Aleksandra","family":"Kaczmarek-Kryszak","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"},{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Dobrzy\u0144ska","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina","family":"Banaszak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"},{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomira","family":"Drzyma\u0142a-Czy\u017c","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02zbb2597","id-type":"ROR","asserted-by":"publisher"}],"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"S0924270826100854_ref119","doi-asserted-by":"publisher","DOI":"10.1179\/1476830512Y.0000000027"},{"key":"S0924270826100854_ref61","first-page":"115","article-title":"PICO: Model for clinical questions","volume":"3","author":"Leonardo","year":"2018","journal-title":"Evidence-Based Medicine and Practice"},{"key":"S0924270826100854_ref104","first-page":"7","article-title":"Dementia: Dementia types","volume":"534","author":"Wilbur","year":"2023","journal-title":"FP essentials"},{"key":"S0924270826100854_ref34","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-013-0092-1"},{"key":"S0924270826100854_ref98","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1176\/ajp.152.9.1349","article-title":"The behavior rating scale for dementia of the consortium to establish a registry for Alzheimer\u2019s disease. 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