{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:47:09Z","timestamp":1785433629854,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"unspecified","delay-in-days":160,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270826100878_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Schizophrenia spectrum disorders (SSD) are complex illnesses influenced by genetic, biological and psycho-social factors, necessitating large clinical deep-phenotyped cohorts. Here, we describe the Region Midt Schizophrenia (RMS) Cohort, which aims to establish such a large, representative cohort with long-term follow-up, enabling large-scale studies on SSD aetiology and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100878_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The RMS cohort includes patients aged \u226515 years diagnosed with a first-episode SSD recruiting at 6 Danish psychiatric hospitals. Baseline and follow-up assessments at 1, 2, 3 and 12 months and 2, 3, 5 and 10 years cover sociodemographic measures, psychotic and negative symptoms, adverse childhood experiences (ACEs), level of functioning, sleep, actigraphy, cognition, side effects and medication adherence. Blood is collected at baseline and months 3 and 12 and at years 2, 3, 5 and 10 enabling comprehensive molecular analyses, for example, genetics and omics. Age-and sex-matched healthy controls will complete a baseline assessment including blood draw. Participants give informed consent for linkage with Danish nationwide register-based data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100878_as3\">\n                    <jats:title>Status and perspectives:<\/jats:title>\n                    <jats:p>By February 23rd, 2026, a total of 131 participants with SSD have been recruited (109 with schizophrenia, median age 25 years (IQR 8), 54% females). Retention rates at 1, 2, 3 and 12 months are 86%, 80%, 78% and 75%, respectively. Our vision is continuous recruitment of 100 participants\/year, establishing a large, deep-phenotyped and representative clinical cohort with long-term follow-up. The RMS cohort will serve as the basis for several studies on aetiological and prognostic factors and is designed to match with similar international cohorts enabling further collaborations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2026.10087","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:12:32Z","timestamp":1781082752000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["The Danish Region Midt Schizophrenia Cohort \u2013 representative, long-term follow-up of first-episode schizophrenia spectrum disorder"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-0063","authenticated-orcid":false,"given":"Nina Friis Bak","family":"Fuglsang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Department for Psychotic Disorders, Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lund","family":"Kobber\u00f8","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Department for Psychotic Disorders, Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Olesen","sequence":"additional","affiliation":[{"name":"Regional Hospital Randers"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"H\u00f8gh","sequence":"additional","affiliation":[{"name":"Regional Hospital Central Jutland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Louise Egholm","family":"Stagis","sequence":"additional","affiliation":[{"name":"Regional Hospital G\u00f8dstrup"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jelle","sequence":"additional","affiliation":[{"name":"Regional Hospital Horsens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Qvist","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Demontis","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Torp","family":"Jensen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Fugger","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"name":"University of Oxford"},{"name":"University of Oxford Centre for Cellular and Molecular Physiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben \u00d8stergaard","family":"Christensen","sequence":"additional","affiliation":[{"name":"Regional Hospital G\u00f8dstrup"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Emborg","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndis","family":"Simonsen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Department for Psychotic Disorders, Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Hove","family":"Thomsen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"name":"Aarhus University Hospital Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Department for Psychotic Disorders, Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-1287","authenticated-orcid":false,"given":"Ole","family":"K\u00f6hler-Forsberg","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01aj84f44","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University"},{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Department for Psychotic Disorders, Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,10]]},"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270826100878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:47:52Z","timestamp":1783932472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270826100878\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"alternative-id":["S0924270826100878"],"URL":"https:\/\/doi.org\/10.1017\/neu.2026.10087","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e46"}}