{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:45:48Z","timestamp":1791971148869,"version":"4.3.4"},"reference-count":85,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":286,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0924270826100970_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 (GLP-1), indicated in the treatment of type 2 diabetes mellitus, influences reward processing, integral to disparate mental disorders. Emerging evidence suggests that GLP-1 receptor mono-agonists (GLP-1RAs) are potential treatment strategies for select mental disorders. Herein, we systematically review preclinical research documenting how GLP-1 and GLP-1RAs may impact reward function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100970_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Relevant studies were identified through Web of Science, OVID (MedLINE, Embase, PsycInfo), and PubMed from database inception to June 28, 2026. Preclinical research investigating the association between GLP-1 and select GLP-1RAs and reward function was included. Reward functions assessed were food-, drug-, and sexual-related reward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100970_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 66 studies met inclusion and were synthesised herein. Taken together, results indicate that GLP-1 and GLP-1RAs affect measures of food-related, drug-associated, and sexual behaviours. GLP-1 administration was associated with a reduction in food intake and gross locomotor activity with respect to approaching and engaging in reward-seeking behaviours. When locally administered in selected brain regions of evaluated animal models, exenatide was associated with reduced substance use, food seeking, and sexual behaviours (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Similarly, liraglutide was observed to attenuate substance and food-related rewards (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In addition, semaglutide was demonstrated to reduce substance and sucrose intake, while dulaglutide is reported to reduce substance intake (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0924270826100970_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Extant preclinical findings demonstrate a trend toward reductions in reward-associated behaviours following GLP-1RA administration. Our findings can also provide rationale and impetus for evaluating GLP-1RAs in the treatment of psychiatric disorders characterised by disturbance in hedonic function and behaviours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/neu.2026.10097","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:51:21Z","timestamp":1791967881000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3238-696X","authenticated-orcid":false,"given":"Yang Jing","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences, University of Toronto"},{"name":"Brain and Cognition Discovery Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8786-1550","authenticated-orcid":false,"given":"Hezekiah Ching Tin","family":"Au","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gia Han","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Toronto"},{"name":"Brain and Cognition Discovery Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Wong","sequence":"additional","affiliation":[{"name":"Brain and Cognition Discovery Foundation"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla M.","family":"Teopiz","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Toronto"},{"name":"Brain and Cognition Discovery Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela T.H.","family":"Kwan","sequence":"additional","affiliation":[{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Toronto"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo B.","family":"Mansur","sequence":"additional","affiliation":[{"name":"University Health Network"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeho Greg","family":"Rhee","sequence":"additional","affiliation":[{"name":"Yale School of Medicine"},{"name":"University of Connecticut School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Ka Ying","family":"Lo","sequence":"additional","affiliation":[{"name":"The University of Hong Kong Li Ka Shing Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-2523","authenticated-orcid":false,"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[{"name":"University of Toronto"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"S0924270826100970_ref42","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-024-01981-5"},{"key":"S0924270826100970_ref82","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0531-4"},{"key":"S0924270826100970_ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.614884"},{"key":"S0924270826100970_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13117"},{"key":"S0924270826100970_ref85","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.769664"},{"key":"S0924270826100970_ref3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00179.2014"},{"key":"S0924270826100970_ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249710"},{"key":"S0924270826100970_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.02.005"},{"key":"S0924270826100970_ref53","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1447"},{"key":"S0924270826100970_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.06.013"},{"key":"S0924270826100970_ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-026-02386-2"},{"key":"S0924270826100970_ref49","unstructured":"National Institute of Mental Health (2024) RDoC Matrix. 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