{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:45:49Z","timestamp":1791971149116,"version":"4.3.4"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":286,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Treatment-resistant mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), remain a significant clinical challenge. A confluence of emerging evidence implicates chronic low-grade inflammation in the pathophysiology of at least a subset of mood disorders, potentially mediating their poor response to traditional therapies. Colchicine, a well-established anti-inflammatory agent used in gout and more recently (at low dose) cardiovascular disease, inhibits microtubule polymerisation and suppresses NLRP3 inflammasome activation. Recent advances in immunopsychiatry suggest NLRP3-mediated pathways are key mediators of mood pathology. This hypothesis-generating paper explores how low-dose colchicine may plausibly serve as a novel augmenting agent in refractory mood disorders by targeting these neuroinflammatory pathways. We present mechanistic rationale, integrate preclinical and translational evidence, review long-term safety data and outline biomarker-guided clinical trial proposals.<\/jats:p>","DOI":"10.1017\/neu.2026.10098","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:51:29Z","timestamp":1791967889000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Low-dose colchicine: a potential augmenting agent in the treatment of refractory mood disorders"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-7959","authenticated-orcid":false,"given":"Ajeet B.","family":"Singh","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02czsnj07","id-type":"ROR","asserted-by":"publisher"}],"name":"Deakin University, School of Medicine, Institute for Mental and Physical Health and Clinical Translation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Skvarc","sequence":"additional","affiliation":[{"name":"Deakin University, School of Psychology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Lago","sequence":"additional","affiliation":[{"name":"Universidad de los Andes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-6946","authenticated-orcid":false,"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02czsnj07","id-type":"ROR","asserted-by":"publisher"}],"name":"Deakin University, School of Medicine, Institute for Mental and Physical Health and Clinical Translation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"S0924270826100982_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13016"},{"key":"S0924270826100982_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.01.014"},{"key":"S0924270826100982_ref30","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412437346"},{"key":"S0924270826100982_ref41","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"S0924270826100982_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61239-2"},{"key":"S0924270826100982_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01919-7"},{"key":"S0924270826100982_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"S0924270826100982_ref24","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050423"},{"key":"S0924270826100982_ref50","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/898393"},{"key":"S0924270826100982_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1214"},{"key":"S0924270826100982_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-200"},{"key":"S0924270826100982_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.001"},{"key":"S0924270826100982_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"S0924270826100982_ref17","first-page":"173","volume-title":"Current topics in behavioral neurosciences","author":"Haroon","year":"2016"},{"key":"S0924270826100982_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.3"},{"key":"S0924270826100982_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2025.115619"},{"key":"S0924270826100982_ref27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204742"},{"key":"S0924270826100982_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.02.002"},{"key":"S0924270826100982_ref22","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666151208113700"},{"key":"S0924270826100982_ref55","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae208"},{"key":"S0924270826100982_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101166"},{"key":"S0924270826100982_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.07.017"},{"key":"S0924270826100982_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.12.010"},{"key":"S0924270826100982_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1475-6"},{"key":"S0924270826100982_ref57","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.495348"},{"key":"S0924270826100982_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1016-x"},{"key":"S0924270826100982_ref1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1435"},{"key":"S0924270826100982_ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010133"},{"key":"S0924270826100982_ref54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021372"},{"key":"S0924270826100982_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03312-3"},{"key":"S0924270826100982_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.07.025"},{"key":"S0924270826100982_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.03.002"},{"key":"S0924270826100982_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.01.013"},{"key":"S0924270826100982_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"S0924270826100982_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109916"},{"key":"S0924270826100982_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf174"},{"key":"S0924270826100982_ref47","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S114542"},{"key":"S0924270826100982_ref49","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050771"},{"key":"S0924270826100982_ref51","doi-asserted-by":"publisher","DOI":"10.1177\/0004867420965697"},{"key":"S0924270826100982_ref48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"S0924270826100982_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-021-01019-4"},{"key":"S0924270826100982_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2003.03040.x"},{"key":"S0924270826100982_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-01095-1"},{"key":"S0924270826100982_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1407529"},{"key":"S0924270826100982_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.167"},{"key":"S0924270826100982_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"S0924270826100982_ref52","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv006"},{"key":"S0924270826100982_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamapsychiatry.4"},{"key":"S0924270826100982_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15946"},{"key":"S0924270826100982_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.02.010"},{"key":"S0924270826100982_ref42","doi-asserted-by":"publisher","DOI":"10.2174\/1871527311201070836"},{"key":"S0924270826100982_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead625"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270826100982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:51:31Z","timestamp":1791967891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270826100982\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"alternative-id":["S0924270826100982"],"URL":"https:\/\/doi.org\/10.1017\/neu.2026.10098","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e56"}}