{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:39:35Z","timestamp":1790595575809,"version":"4.1.0"},"reference-count":91,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Camb. prisms Precis. med."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>More than 50 million older people worldwide are suffering from dementia, and this number is estimated to increase to 150 million by 2050. Greater caregiver burdens and financial impacts on the healthcare system are expected as we wait for an effective treatment for dementia. Researchers are constantly exploring new therapies and screening approaches for the early detection of dementia. Artificial intelligence (AI) is widely applied in dementia research, including machine learning and deep learning methods for dementia diagnosis and progression detection. Computerized apps are also convenient tools for patients and caregivers to monitor cognitive function changes. Furthermore, social robots can potentially provide daily life support or guidance for the elderly who live alone. This review aims to provide an overview of AI applications in dementia research. We divided the applications into three categories according to different stages of cognitive impairment: (1) cognitive screening and training, (2) diagnosis and prognosis for dementia, and (3) dementia care and interventions. There are numerous studies on AI applications for dementia research. However, one challenge that remains is comparing the effectiveness of different AI methods in real clinical settings.<\/jats:p>","DOI":"10.1017\/pcm.2022.10","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T06:37:00Z","timestamp":1670308620000},"source":"Crossref","is-referenced-by-count":28,"title":["Applications of artificial intelligence in dementia research"],"prefix":"10.1017","volume":"1","author":[{"given":"Kelvin K. F.","family":"Tsoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-5246","authenticated-orcid":false,"given":"Pingping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Maritza","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi R.","family":"Titiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana W.","family":"Capuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"S2752614322000102_r82","doi-asserted-by":"publisher","DOI":"10.1007\/s10489-021-02454-8"},{"key":"S2752614322000102_r45","unstructured":"Luz, S , de la Fuente, S and Albert, P (2018) A method for analysis of patient speech in dialogue for dementia detection. Preprint, https:\/\/arxiv.org\/abs\/1811.09919."},{"key":"S2752614322000102_r46","doi-asserted-by":"publisher","DOI":"10.21437\/Interspeech.2020-2571"},{"key":"S2752614322000102_r27","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09363-4"},{"key":"S2752614322000102_r14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213430"},{"key":"S2752614322000102_r7","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180607124038"},{"key":"S2752614322000102_r23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1006\/brcg.2001.1377","article-title":"Distinct patterns of spontaneous speech deterioration: an early predictor of Alzheimer\u2019s disease","volume":"48","author":"Forbes","year":"2002","journal-title":"Brain and Cognition"},{"key":"S2752614322000102_r11","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2021.1914755"},{"key":"S2752614322000102_r20","doi-asserted-by":"publisher","DOI":"10.1021\/ci500574n"},{"key":"S2752614322000102_r51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.08.006"},{"key":"S2752614322000102_r31","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1244-6"},{"key":"S2752614322000102_r54","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00437"},{"key":"S2752614322000102_r72","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-019-1469-0"},{"key":"S2752614322000102_r53","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.1.15"},{"key":"S2752614322000102_r74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2020.103573"},{"key":"S2752614322000102_r81","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2017-0324"},{"key":"S2752614322000102_r4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540180063015"},{"key":"S2752614322000102_r60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"S2752614322000102_r61","unstructured":"Prince, M , Comas-Herrera, A , Knapp, M , Guerchet, M and Karagiannidou, M (2016) World Alzheimer Report 2016: Improving Healthcare for People Living with Dementia: Coverage, Quality and Costs Now and in the Future. Alzheimer\u2019s Disease International. Available at https:\/\/www.alz.co.uk\/research\/world-report-2016."},{"key":"S2752614322000102_r91","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5629090"},{"key":"S2752614322000102_r86","doi-asserted-by":"publisher","DOI":"10.1109\/ICRA.2013.6630717"},{"key":"S2752614322000102_r56","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics6010006"},{"key":"S2752614322000102_r83","doi-asserted-by":"publisher","DOI":"10.21437\/Interspeech.2017-112"},{"key":"S2752614322000102_r3","doi-asserted-by":"publisher","DOI":"10.3390\/pr9020264"},{"key":"S2752614322000102_r63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21330-0"},{"key":"S2752614322000102_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2020.102102"},{"key":"S2752614322000102_r16","first-page":"165","article-title":"EEG feature extraction and classification of Alzheimer\u2019s disease using support vector machine classifier","volume":"6","author":"Deepa","year":"2017","journal-title":"International Journal of Electronics, Electrical and Computational System"},{"key":"S2752614322000102_r55","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"S2752614322000102_r19","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.8.1261"},{"key":"S2752614322000102_r21","doi-asserted-by":"publisher","DOI":"10.1002\/med.21709"},{"key":"S2752614322000102_r49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.59275\/j.melba.2021-2dcc","article-title":"The Alzheimer\u2019s disease prediction of longitudinal evolution (TADPOLE) challenge: results after 1 year follow-up","volume":"1","author":"Marinescu","year":"2021","journal-title":"Journal of Machine Learning for Biomedical Imaging"},{"key":"S2752614322000102_r67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77220-w"},{"key":"S2752614322000102_r78","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0024-5"},{"key":"S2752614322000102_r38","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(86)90008-9"},{"key":"S2752614322000102_r15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52301.x"},{"key":"S2752614322000102_r48","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12638"},{"key":"S2752614322000102_r5","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00369"},{"key":"S2752614322000102_r62","first-page":"CD010803","article-title":"CSF tau and the CSF tau\/ABeta ratio for the diagnosis of Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI)","volume":"3","author":"Ritchie","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S2752614322000102_r25","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"S2752614322000102_r70","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2011.6090374"},{"key":"S2752614322000102_r64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2016.03.001"},{"key":"S2752614322000102_r80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002482"},{"key":"S2752614322000102_r84","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2019.1594831"},{"key":"S2752614322000102_r89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.10.025"},{"key":"S2752614322000102_r90","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027062"},{"key":"S2752614322000102_r42","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooab052"},{"key":"S2752614322000102_r40","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare8020073"},{"key":"S2752614322000102_r43","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031937"},{"key":"S2752614322000102_r66","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0599-5"},{"key":"S2752614322000102_r37","doi-asserted-by":"publisher","DOI":"10.3390\/app11178184"},{"key":"S2752614322000102_r57","first-page":"519","article-title":"Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: a systematic review","volume":"10","author":"Pellegrini","year":"2018","journal-title":"Alzheimer\u2019s and Dementia: Diagnosis, Assessment and Disease Monitoring"},{"key":"S2752614322000102_r76","doi-asserted-by":"publisher","DOI":"10.1142\/S0129065721300023"},{"key":"S2752614322000102_r30","doi-asserted-by":"publisher","DOI":"10.1080\/01688638608405175"},{"key":"S2752614322000102_r79","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38793-3"},{"key":"S2752614322000102_r32","first-page":"e12305","article-title":"Wearable multimodal sensors for the detection of behavioral and psychological symptoms of dementia using personalized machine learning models","volume":"14","author":"Iaboni","year":"2022","journal-title":"Alzheimer\u2019s and Dementia: Diagnosis, Assessment and Disease Monitoring"},{"key":"S2752614322000102_r34","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00648"},{"key":"S2752614322000102_r35","volume-title":"Rhythms of Dialogue","volume":"8","author":"Jaffe","year":"1970"},{"key":"S2752614322000102_r6","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100005497"},{"key":"S2752614322000102_r50","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"S2752614322000102_r58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"S2752614322000102_r22","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00951-z"},{"key":"S2752614322000102_r87","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123140"},{"key":"S2752614322000102_r24","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200888"},{"key":"S2752614322000102_r36","first-page":"6502","article-title":"Automatic detection of EEG as biomarker using deep learning: a review","volume":"25","author":"Jaya Shree","year":"2021","journal-title":"Annals of the Romanian Society for Cell Biology"},{"key":"S2752614322000102_r41","volume-title":"ImageNet Classification with Deep Convolutional Neural Networks","volume":"25","author":"Krizhevsky","year":"2012"},{"key":"S2752614322000102_r88","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/jcc.21411","article-title":"In silico prediction and screening of gamma-secretase inhibitors by molecular descriptors and machine learning methods","volume":"31","author":"Yang","year":"2010","journal-title":"Journal of Computational Chemistry"},{"key":"S2752614322000102_r8","doi-asserted-by":"publisher","DOI":"10.1007\/s41233-019-0028-2"},{"key":"S2752614322000102_r71","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1059-y"},{"key":"S2752614322000102_r13","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-12-S1-S2"},{"key":"S2752614322000102_r73","doi-asserted-by":"publisher","DOI":"10.1007\/s12553-020-00426-5"},{"key":"S2752614322000102_r59","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00141"},{"key":"S2752614322000102_r26","doi-asserted-by":"publisher","DOI":"10.1145\/3469653"},{"key":"S2752614322000102_r69","doi-asserted-by":"publisher","DOI":"10.3390\/s21113786"},{"key":"S2752614322000102_r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2019.105242"},{"key":"S2752614322000102_r77","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.19.2964"},{"key":"S2752614322000102_r75","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80312-2"},{"key":"S2752614322000102_r47","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1232-4"},{"key":"S2752614322000102_r29","first-page":"6245","article-title":"Advances in natural language processing","volume":"349","author":"Hirschberg","year":"2006","journal-title":"Science"},{"key":"S2752614322000102_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101506"},{"key":"S2752614322000102_r33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2019.12.006"},{"key":"S2752614322000102_r44","doi-asserted-by":"publisher","DOI":"10.1186\/s13638-017-0993-1"},{"key":"S2752614322000102_r1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt269"},{"key":"S2752614322000102_r2","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"S2752614322000102_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.04.004"},{"key":"S2752614322000102_r12","doi-asserted-by":"publisher","DOI":"10.1145\/3292500.3330690"},{"key":"S2752614322000102_r68","first-page":"933","article-title":"A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: results from the European medical information framework for Alzheimer disease biomarker discovery cohort","volume":"5","author":"Stamate","year":"2019","journal-title":"Alzheimer\u2019s and Dementia: Translational Research and Clinical Interventions"},{"key":"S2752614322000102_r39","doi-asserted-by":"publisher","DOI":"10.4065\/78.10.1290"},{"key":"S2752614322000102_r52","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0312"},{"key":"S2752614322000102_r10","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120972331"},{"key":"S2752614322000102_r17","doi-asserted-by":"publisher","DOI":"10.1007\/s00521-015-2113-7"},{"key":"S2752614322000102_r85","volume-title":"The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","year":"1992"}],"container-title":["Cambridge Prisms: Precision Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2752614322000102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T10:09:50Z","timestamp":1701511790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2752614322000102\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":91,"alternative-id":["S2752614322000102"],"URL":"https:\/\/doi.org\/10.1017\/pcm.2022.10","relation":{"has-review":[{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr1","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr6","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr7","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr8","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr2","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr3","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr4","asserted-by":"object"},{"id-type":"doi","id":"10.1017\/pcm.2022.10.pr5","asserted-by":"object"}]},"ISSN":["2752-6143"],"issn-type":[{"value":"2752-6143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]},"article-number":"e9"}}