{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:11:42Z","timestamp":1771873902884,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>The Ministry of Health in Sri Lanka commenced a vitamin A supplementation programme of school children with a megadose of 105\u00a0\u03bcmol (100\u00a0000\u00a0IU) vitamin A in school years 1, 4 and 7 (approximately 5-, 9- and 12-year-olds, respectively) in 2001. We evaluated the vitamin A supplementation programme of school children in a rural area of Sri Lanka. A cross-sectional study was conducted among children supplemented with an oral megadose of vitamin A (105\u00a0\u03bcmol; <jats:italic>n<\/jats:italic> 452) and children not supplemented (controls; <jats:italic>n<\/jats:italic> 294) in Grades 1\u20135. Children were clinically examined and a sample of blood was taken for serum vitamin A concentration estimation by HPLC. Socio-demographic information was obtained from children or mothers. Supplemented children had a higher proportion of males and stunted children, were younger and lived under poorer conditions as compared to controls. There was no difference in the prevalences of eye signs and symptoms of vitamin A deficiency in the two groups. Supplemented children had higher serum vitamin A concentrations than controls (1\u00b74 (<jats:sc>sd<\/jats:sc> 0\u00b749) \u03bcmol\/l <jats:italic>v.<\/jats:italic> 1\u00b72 (<jats:sc>sd<\/jats:sc> 0\u00b752) \u03bcmol\/l). The serum vitamin A concentrations were 1\u00b76 (<jats:sc>sd<\/jats:sc> 0\u00b745), 1\u00b74 (<jats:sc>sd<\/jats:sc> 0\u00b750), 1\u00b73 (<jats:sc>sd<\/jats:sc> 0\u00b744) and 1\u00b71 (<jats:sc>sd<\/jats:sc> 0\u00b743) \u03bcmol\/l in children supplemented within 1, 1\u20136, 7\u201312 and 13\u201318 months of supplementation, respectively. Vitamin A concentrations were significantly greater than controls if supplementation was carried out within 6 months after adjustment. The oral megadose of 105\u00a0\u03bcmol vitamin A maintained serum vitamin A concentrations for 6 months in school children.<\/jats:p>","DOI":"10.1017\/s0007114507191923","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T10:45:49Z","timestamp":1168598749000},"page":"153-159","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the effectiveness of the national vitamin A supplementation programme among school children in Sri Lanka"],"prefix":"10.1017","volume":"97","author":[{"given":"Thennakoon M. J. C.","family":"Madatuwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanath T. C.","family":"Mahawithanage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udumalagala G.","family":"Chandrika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Errol R.","family":"Jansz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda R.","family":"Wickremasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"S0007114507191923_ref20","doi-asserted-by":"publisher","DOI":"10.1177\/156482650402500401"},{"key":"S0007114507191923_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.3.489"},{"key":"S0007114507191923_ref12","doi-asserted-by":"publisher","DOI":"10.1179\/136485905X51436"},{"key":"S0007114507191923_ref32","volume-title":"Physical Status: The Use and Interpretation of Anthropometry","year":"1995"},{"key":"S0007114507191923_ref31","volume-title":"Vitamin A Deficiency and its Consequences. 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