{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:09Z","timestamp":1791230949937,"version":"4.1.0"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>There are few data on the prevalence of riboflavin deficiency in sub-Saharan Africa, and it remains unclear whether riboflavin status influences the risk for anaemia. The aims of this study were to: (1) measure the prevalence of riboflavin deficiency in children in south-central C\u00f4te d'Ivoire; (2) estimate the riboflavin content of the local diet; and (3) determine if riboflavin deficiency predicts anaemia and\/or iron deficiency. In 5- to 15-year-old children (<jats:italic>n<\/jats:italic>281), height, weight, haemoglobin (Hb), whole blood zinc protoporphyrin (ZPP), erythrocyte glutathione reductase activity coefficient (EGRAC), serum retinol, C-reactive protein (CRP) and prevalence of<jats:italic>Plasmodium<\/jats:italic>spp. (asymptomatic malaria) and<jats:italic>Schistosoma haematobium<\/jats:italic>(bilharziosis) infections were measured. Three-day weighed food records were kept in twenty-four households. Prevalence of anaemia in the sample was 52\u00a0%; 59\u00a0% were iron-deficient based on an elevated ZPP concentration, and 36\u00a0% suffered from iron deficiency anaemia.<jats:italic>Plasmodium<\/jats:italic>parasitaemia was found in 49\u00a0% of the children. Nineteen percent of the children were infected with<jats:italic>S. haematobium<\/jats:italic>. Median riboflavin intake in 5- to 15-year-old children from the food records was 0\u00b742\u00a0mg\/d, ~47\u00a0% of the estimated average requirement for this age group. Prevalence of riboflavin deficiency was 65\u00a0%, as defined by an EGRAC value &gt;1\u00b72. Age, elevated CRP and iron deficiency were significant predictors of Hb. Riboflavin-deficient children free of malaria were more likely to be iron deficient (odds ratio; 3\u00b707; 95\u00a0% CI 1\u00b712, 8\u00b741). In conclusion, nearly two-thirds of school-age children in south-central C\u00f4te d'Ivoire are mildly riboflavin deficient. Riboflavin deficiency did not predict Hb and\/or anaemia, but did predict iron deficiency among children free of malaria.<\/jats:p>","DOI":"10.1017\/s0007114507665180","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T11:17:20Z","timestamp":1174907840000},"page":"970-976","source":"Crossref","is-referenced-by-count":45,"title":["Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in C\u00f4te d'Ivoire"],"prefix":"10.1017","volume":"97","author":[{"given":"Fabian","family":"Rohner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Wegmueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas B.","family":"Tschannen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Hurrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"S0007114507665180_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700650228"},{"key":"S0007114507665180_ref32","first-page":"413","article-title":"The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia","volume":"37","author":"Powers","year":"1983","journal-title":"Hum Nutr Clin Nutr"},{"key":"S0007114507665180_ref11","first-page":"97","article-title":"The effect of riboflavin on the hematologic changes in iron supplementation of schoolchildren","volume":"11","author":"Charoenlarp","year":"1980","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"S0007114507665180_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.6.1352"},{"key":"S0007114507665180_ref49","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.7.1814"},{"key":"S0007114507665180_ref15","volume-title":"Food Composition Table for Use in Africa","year":"1968"},{"key":"S0007114507665180_ref34","first-page":"753","article-title":"Interpretation of erythrocyte glutathione reductase activation test values for assessing riboflavin status","volume":"46","author":"Prasad","year":"1992","journal-title":"Eur J Clin Nutr"},{"key":"S0007114507665180_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90329-3"},{"key":"S0007114507665180_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.11.3972S"},{"key":"S0007114507665180_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(58)90113-5"},{"key":"S0007114507665180_ref39","author":"Staubli-Asobayire","year":"2000"},{"key":"S0007114507665180_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601953"},{"key":"S0007114507665180_ref33","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880047"},{"key":"S0007114507665180_ref10","first-page":"136","article-title":"The effects of riboflavin administration on iron metabolism parameters in a school-going population","volume":"49","author":"Buzina","year":"1979","journal-title":"Int J Vitam Nutr Res"},{"key":"S0007114507665180_ref53","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.3.615"},{"key":"S0007114507665180_ref28","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19950019"},{"key":"S0007114507665180_ref42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-6047.2002.00310.x"},{"key":"S0007114507665180_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91565-8"},{"key":"S0007114507665180_ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000177696"},{"key":"S0007114507665180_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.6.1834"},{"key":"S0007114507665180_ref2","volume-title":"Fourth Report on the World Nutrition Situation","year":"2000"},{"key":"S0007114507665180_ref3","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19860097"},{"key":"S0007114507665180_ref6","doi-asserted-by":"publisher","DOI":"10.2114\/jpa.20.81"},{"key":"S0007114507665180_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(92)90139-J"},{"key":"S0007114507665180_ref8","unstructured":"Bundesinstitut f\u00fcr gesundheitlichen Verbraucherschutz und Veterin\u00e4rmedizin (1996) Bundeslebensmittelschl\u00fcssel. 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