{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:51:59Z","timestamp":1792248719242,"version":"4.4.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>Excessive iodine induces thyroid dysfunction. However, the effect of excessive iodine exposure on maternal\u2013fetal thyroid hormone metabolism and on the expression of genes involved in differentiation, growth and development is poorly understood. Since a thyroid hormone receptor response element was found in the<jats:italic>Hoxc8<\/jats:italic>promoter region,<jats:italic>Hoxc8<\/jats:italic>expression possibly regulated by excessive iodine exposure was firstly investigated. In the present study, Balb\/C mice were given different doses of iodine in the form of potassium iodate (KIO<jats:sub>3<\/jats:sub>) at the levels of 0 (sterile water), 1\u00b75, 3\u00b70, 6\u00b70, 12\u00b70 and 24\u00b70\u00a0\u03bcg\/ml in drinking water for 4 months, then were mated. On 12\u00b75\u00a0d postcoitum, placental type 2 and type 3 deiodinase activities and fetal<jats:italic>Hoxc8<\/jats:italic>expression were determined. The results showed that excessive iodine exposure above 1\u00b75\u00a0\u03bcg\/ml resulted in an increase of total thyroxine and a decrease of total triiodothyronine in the serum of maternal mice, which was mainly associated with the inhibition of type 1 deiodinase activity in liver and kidney. Placental type 2 deiodinase activity decreased, showing an inverse relationship with maternal thyroxine level.<jats:italic>Hoxc8<\/jats:italic>\u00a0mRNA and protein expression at 12\u00b75\u00a0d postcoitum embryos were down regulated. Because<jats:italic>Hoxc8<\/jats:italic>plays an important role in normal skeletal development, this finding provides a possible explanation for the skeletal malformation induced by excessive iodine exposure and also provides a new clue to study the relationship between iodine or thyroid hormones and<jats:italic>Hox<\/jats:italic>gene expression pattern.<\/jats:p>","DOI":"10.1017\/s0007114507691909","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T16:41:18Z","timestamp":1177432878000},"page":"116-122","source":"Crossref","is-referenced-by-count":9,"title":["Effect of excessive iodine exposure on the placental deiodinase activities and<i>Hoxc8<\/i>expression during mouse embryogenesis"],"prefix":"10.1017","volume":"98","author":[{"given":"Xue 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