{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:10:58Z","timestamp":1773299458221,"version":"3.50.1"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Neonates are particularly susceptible to malnutrition due to their limited reserves of micronutrients and their rapid growth. In the present study, we examined the effect of vitamin C deficiency on markers of oxidative stress in plasma, liver and brain of weanling guinea pigs. Vitamin C deficiency caused rapid and significant depletion of ascorbate (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), tocopherols (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and glutathione (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), and a decrease in superoxide dismutase activity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) in the liver, while protein oxidation was significantly increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011). No changes in lipid oxidation or oxidatively damaged DNA were observed in this tissue. In the brain, the pattern was markedly different. Of the measured antioxidants, only ascorbate was significantly depleted (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), but in contrast to the liver, ascorbate oxidation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7034), lipid oxidation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), DNA oxidation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b713) and DNA incision repair (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7014) were all increased, while protein oxidation decreased (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003). The results show that the selective preservation of brain ascorbate and induction of DNA repair in vitamin C-deficient weanling guinea pigs is not sufficient to prevent oxidative damage. Vitamin C deficiency may therefore be particularly adverse during the neonatal period.<\/jats:p>","DOI":"10.1017\/s0007114507787457","type":"journal-article","created":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T10:21:30Z","timestamp":1183976490000},"page":"1116-1119","source":"Crossref","is-referenced-by-count":61,"title":["Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain"],"prefix":"10.1017","volume":"98","author":[{"given":"Jens","family":"Lykkesfeldt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Perez Trueba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik 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