{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:05:17Z","timestamp":1789862717738,"version":"4.0.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T00:00:00Z","timestamp":1184803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>To determine the effect of feeding formula containing long-chain PUFA (LCP) on immune function, healthy term infants were randomised at age 2 weeks to either a standard term formula (Formula; <jats:italic>n<\/jats:italic> 14) or the same formula supplemented with the LCP 20\u00a0:\u00a04<jats:italic>n<\/jats:italic>-6 and 22\u00a0:\u00a06<jats:italic>n<\/jats:italic>-3 (Formula+LCP; <jats:italic>n<\/jats:italic> 16). Peripheral blood was collected at 2 and 6 weeks to measure immune cell response (the rate of [<jats:sup>3<\/jats:sup>H]thymidine uptake and cytokine production after stimulation with phytohaemagglutinin (PHA)). Compared with cells from infants receiving only human milk (HM), the rate of [<jats:sup>3<\/jats:sup>H]thymidine uptake in response to PHA, but not IL-2 production, was lower for Formula+LCP infants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Compared with HM-fed infants, Formula-fed infants (but not Formula+LCP infants) produced more TNF-\u03b1 (unstimulated) and had a fewer CD3<jats:sup>+<\/jats:sup>CD44<jats:sup>+<\/jats:sup> cells before stimulation and fewer CD11c<jats:sup>+<\/jats:sup> cells post-stimulation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). However, compared with Formula-fed infants, the Formula+LCP infants had an immune cell distribution (higher percentage CD3<jats:sup>+<\/jats:sup>CD44<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup>CD28<jats:sup>+<\/jats:sup> cells) and cytokine profile (lower production of TNF-\u03b1 post-stimulation) that did not differ from HM infants. Additionally, it was found that feeding infants formula during the first 10\u00a0d of life influenced immune function. These infants had a higher percentage of CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>CD28<jats:sup>+<\/jats:sup>, and lower percentage of CD14<jats:sup>+<\/jats:sup> cells and produced more TNF-\u03b1 and interferon-\u03b3 after PHA stimulation than HM-fed infants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). These results demonstrate that early diet influences both the presence of specific cell types and function of infant blood immune cells. Since many diseases have a strong immunological component, these immune changes may be of physiological importance to the developing infant.<\/jats:p>","DOI":"10.1017\/s0007114507791845","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T09:58:33Z","timestamp":1184839113000},"page":"91-99","source":"Crossref","is-referenced-by-count":63,"title":["Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates"],"prefix":"10.1017","volume":"99","author":[{"given":"Catherine J.","family":"Field","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Van Aerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay E.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thomas Clandinin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,7,19]]},"reference":[{"key":"S0007114507791845_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00266-9"},{"key":"S0007114507791845_ref25","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199905010-00006"},{"key":"S0007114507791845_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051162"},{"key":"S0007114507791845_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-199803000-00003"},{"key":"S0007114507791845_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.607"},{"key":"S0007114507791845_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.1.123"},{"key":"S0007114507791845_ref23","first-page":"930","article-title":"Supraventricular tachycardia and eczema due to milk allergy","volume":"24","author":"Taylor","year":"1995","journal-title":"Aust Fam Physician"},{"key":"S0007114507791845_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02562264"},{"key":"S0007114507791845_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00774.x"},{"key":"S0007114507791845_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.357s"},{"key":"S0007114507791845_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01851.x"},{"key":"S0007114507791845_ref22","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200203000-00009"},{"key":"S0007114507791845_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-999-0441-1"},{"key":"S0007114507791845_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.1.1"},{"key":"S0007114507791845_ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01627.x"},{"key":"S0007114507791845_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90225-9"},{"key":"S0007114507791845_ref4","first-page":"1128","article-title":"Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis","volume":"6","author":"Bartuzi","year":"2000","journal-title":"Med Sci Monit"},{"key":"S0007114507791845_ref5","doi-asserted-by":"publisher","DOI":"10.1191\/0960327102ht288oa"},{"key":"S0007114507791845_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200009000-00017"},{"key":"S0007114507791845_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92632-3"},{"key":"S0007114507791845_ref17","doi-asserted-by":"publisher","DOI":"10.4141\/A03-123"},{"key":"S0007114507791845_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0193-y"},{"key":"S0007114507791845_ref24","doi-asserted-by":"publisher","DOI":"10.1081\/IMM-100105065"},{"key":"S0007114507791845_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.1.37"},{"key":"S0007114507791845_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0772-y"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114507791845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T15:17:24Z","timestamp":1556723844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114507791845\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,19]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0007114507791845"],"URL":"https:\/\/doi.org\/10.1017\/s0007114507791845","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,19]]}}}