{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:36:09Z","timestamp":1783460169676,"version":"3.55.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>Chicory roots are rich in inulin that is degraded into SCFA in the caecum and colon. Whole-body SCFA metabolism was investigated in rats during food deprivation and postprandial states. After 22\u00a0h of food deprivation, sixteen rats received an IV injection of radioactive<jats:sup>14<\/jats:sup>C-labelled SCFA. The volume of distribution and the fractional clearance rate of SCFA were 0\u00b725\u20130\u00b727 litres\/kg and 5\u00b74\u20135\u00b79\u00a0%\/min, respectively. The half-life in the first extracellular rapidly decaying compartment was between 0\u00b79 and 1\u00b74\u00a0min. After 22\u00a0h of food deprivation, another seventeen rats received a primed continuous IV infusion of<jats:sup>13<\/jats:sup>C-labelled SCFA for 2\u00a0h. Isotope enrichment (<jats:sup>13<\/jats:sup>C) of SCFA was determined in peripheral arterial blood by MS. Peripheral acetate, propionate and butyrate turnover rates were 29, 4 and 0\u00b73\u00a0\u03bcmol\/kg per min respectively. Following 4 weeks of treatment with chicory root or control diets, eighteen fed rats received a primed continuous IV infusion of<jats:sup>13<\/jats:sup>C-labelled SCFA for 2\u00a0h. Intestinal degradation of dietary chicory lowered caecal pH, enhanced caecal and colonic weights, caecal SCFA concentrations and breath H<jats:sub>2<\/jats:sub>.The diet with chicory supplementation enhanced peripheral acetate turnover by 25\u00a0% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017) concomitant with an increase in plasma acetate concentration. There were no changes in propionate or butyrate turnovers. In conclusion, by setting up a multi-tracer approach to simultaneously assess the turnovers of acetate, propionate and butyrate it was demonstrated that a chronic chicory-rich diet significantly increases peripheral acetate turnover but not that of propionate or butyrate in rats.<\/jats:p>","DOI":"10.1017\/s0007114507815790","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T10:52:29Z","timestamp":1188557549000},"page":"287-296","source":"Crossref","is-referenced-by-count":19,"title":["Chicory increases acetate turnover, but not propionate and butyrate peripheral turnovers in 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