{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T08:50:54Z","timestamp":1772441454183,"version":"3.50.1"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Lactic acid bacteria have traditionally been thought to have immunomodulating effects. To verify this property,<jats:italic>Lactobacillus plantarum<\/jats:italic>was orally administered to mice (5\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup>colony forming units (c.f.u.)), prior to infection with<jats:italic>Listeria monocytogenes<\/jats:italic>in order to evaluate the host resistance against an infectious micro-organism and to better define the influence of<jats:italic>L. plantarum<\/jats:italic>on such responses. Balb\/c mice were treated daily with<jats:italic>L. plantarum<\/jats:italic>or received PBS (sham-treated mice as controls) for 4 weeks. Subsequently, mice were intravenously infected with a clinical isolate of<jats:italic>L. monocytogenes<\/jats:italic>. Our study revealed that the administration of<jats:italic>L. plantarum<\/jats:italic>did not significantly increase the survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b713) of mice (fifteen in each group) after<jats:italic>L. monocytogenes<\/jats:italic>infection (10<jats:sup>6<\/jats:sup>\u00a0c.f.u.\/ml), whereas a sub-lethal dose of<jats:italic>L. monocytogenes<\/jats:italic>(10<jats:sup>5<\/jats:sup>\u00a0c.f.u.\/ml) was eliminated from liver and spleen 5\u00a0d after the challenge in both<jats:italic>L. plantarum<\/jats:italic>- and sham-treated mice (<jats:italic>n<\/jats:italic>5). Nevertheless, the levels of IL-1\u03b2 and IL-6 from sera of orally administered<jats:italic>L. plantarum<\/jats:italic>were drastically reduced at 0, 4 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and 6\u00a0d after<jats:italic>L. monocytogenes<\/jats:italic>infection, whereas TNF-\u03b1 production was unaltered. In conclusion, administration of<jats:italic>L. plantarum<\/jats:italic>reduced pro-inflammatory IL production after challenge with<jats:italic>L. monocytogenes<\/jats:italic>, although it did not significantly impact the survival of mice. We speculate that<jats:italic>L. plantarum<\/jats:italic>could exert anti-inflammatory effects, which may represent an important model to reduce inflammatory disorders. Therefore, further studies in human subjects should determine the role of<jats:italic>L. plantarum<\/jats:italic>as an immunomodulatory micro-organism and its relationship in the host protection to pathogens.<\/jats:p>","DOI":"10.1017\/s0007114507832533","type":"journal-article","created":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T11:05:34Z","timestamp":1190804734000},"page":"819-825","source":"Crossref","is-referenced-by-count":29,"title":["Orally administered<i>Lactobacillus plantarum<\/i>reduces pro-inflammatory interleukin secretion in sera from<i>Listeria monocytogenes<\/i>infected mice"],"prefix":"10.1017","volume":"99","author":[{"given":"Elena","family":"Puertollano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda 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