{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:30:59Z","timestamp":1774074659047,"version":"3.50.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T00:00:00Z","timestamp":1191542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>Soyabean oil-based emulsions high in linoleic acid used in parenteral nutrition (PN) could interfere with immune function and may increase the risk of septic complications. Olive oil-based emulsions, high in oleic acid, could have fewer immune effects. We compared the effects of a soyabean oil-based emulsion<jats:italic>v<\/jats:italic>. an olive oil-based emulsion on infection rate, appearance of new infection episodes, leucocyte count (peak and evolution), acute-phase proteins, and major health outcomes in intensive care unit (ICU) adult patients receiving PN. The study was designed as an observational, retrospective, single-centre, cohort study in a general ICU. Patients in the SOYA cohort (<jats:italic>n<\/jats:italic>16) received a soyabean oil-based emulsion and patients in the OLIVE cohort (<jats:italic>n<\/jats:italic>23), an olive oil-based emulsion. Both cohorts had similar basal characteristics and received a similar energy load. The SOYA cohort received an oleic acid:linoleic acid ratio of 0\u00b743 and the OLIVE cohort 2\u00b799 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). No differences were observed in infection rate and appearance, acute-phase proteins, and major health outcomes. At the end of PN, blood leucocyte count decreased by 3\u00b725\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>cells\/l in the SOYA cohort and increased by 4\u00b751\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>cells\/l in the OLIVE cohort from baseline values (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7036). Peak leucocyte count presented a trend for a higher value in the OLIVE cohort<jats:italic>v<\/jats:italic>. the SOYA cohort (18\u00b786<jats:italic>v<\/jats:italic>. 15\u00b728\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>cells\/l;<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7078). The use of an olive oil-based emulsion in PN had no effect on infection, acute-phase proteins, major health outcomes, and presented higher leucocyte count at the end of PN and a trend to higher peak leucocyte count when compared with soyabean oil-based emulsion in ICU patients.<\/jats:p>","DOI":"10.1017\/s0007114507837433","type":"journal-article","created":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T10:18:47Z","timestamp":1191579527000},"page":"846-854","source":"Crossref","is-referenced-by-count":34,"title":["Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition"],"prefix":"10.1017","volume":"99","author":[{"given":"Javier","family":"Mateu-de 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