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Whole-body glucose metabolism after oral glucose was studied in eight haemodialysis patients before and after a 3-week oral fish oil supplementation (i.e. EPA + DHA at 1\u00b78\u00a0g\/d). Plasma glucose fluxes were traced by using [6,6-<jats:sup>2<\/jats:sup>H<jats:sub>2<\/jats:sub>]glucose infusion. Substrate oxidation was determined by using indirect calorimetry. Each patient was studied in the basal state and over the 6\u00a0h following absorption of a 1\u00a0g\/kg glucose load. Energy expenditure in response to glucose re-increased over the last 2\u00a0h of the experiment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), which coincided with an increase in plasma catecholamines, especially epinephrine (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), strongly suggesting a sympathoadrenal overactivity. Fish oil supplementation blunted both re-increase in thermogenic response and concomitant increase in plasma epinephrine, but not in plasma norepinephrine, over the last 2\u00a0h of the experiment. Fish oil did not alter either whole-body glucose metabolism or substrate oxidation. These data show that in haemodialysis patients, fish oil attenuates adrenal overactivity induced by oral glucose but does not modulate whole-body glucose metabolism and insulin sensitivity.<\/jats:p>","DOI":"10.1017\/s0007114507843534","type":"journal-article","created":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T11:04:39Z","timestamp":1193915079000},"page":"1041-1047","source":"Crossref","is-referenced-by-count":14,"title":["Fish oil attenuates adrenergic overactivity without altering glucose metabolism during an oral glucose load in haemodialysis 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