{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:36:05Z","timestamp":1791178565979,"version":"4.1.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Though common in older adults, anaemia is unexplained in about one-third of cases. As a rare cause of anaemia and neutropenia, Cu deficiency could account for some cases of unexplained anaemia. We examined the relationship between serum Cu and unexplained anaemia among 11\u00a0240 participants in the Second National Health and Nutrition Examination Survey (NHANES II): 638 (5\u00b77\u00a0% of all adults) were anaemic; 421 (3\u00b77\u00a0%) were not explained by deficiencies of vitamin B<jats:sub>12<\/jats:sub>, folate or Fe, chronic illness or renal disease. Spline regression showed a U-shaped relationship between serum Cu levels and unexplained anaemia, indicating that both high and low serum Cu levels are associated with unexplained anaemia in adults. Chronic inflammation and mild Fe deficiency could account for the association between unexplained anaemia and elevated Cu levels. On the other hand, the finding of hypocupraemia in a subset of adults with unexplained anaemia suggests that Cu deficiency may be a common reversible cause of anaemia in adults.<\/jats:p>","DOI":"10.1017\/s0007114507864828","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T10:11:11Z","timestamp":1195639871000},"page":"1226-1229","source":"Crossref","is-referenced-by-count":29,"title":["The association between serum copper and anaemia in the adult Second National Health and Nutrition Examination Survey (NHANES II) population"],"prefix":"10.1017","volume":"99","author":[{"given":"Mary Ann","family":"Knovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Il'yasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"S0007114507864828_ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"S0007114507864828_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20656"},{"key":"S0007114507864828_ref10","first-page":"199","article-title":"Copper levels in inflammatory conditions","volume":"8","author":"Brown","year":"1981","journal-title":"Agents Actions Suppl"},{"key":"S0007114507864828_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.1.67"},{"key":"S0007114507864828_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540360041028"},{"key":"S0007114507864828_ref4","volume-title":"Hematological and Nutritional Biochemistry Reference Data for Persons 6 Months\u201374 Years of Age: United States, 1976\u201380. Vital and Health Statistics","author":"Fulwood","year":"1982"},{"key":"S0007114507864828_ref3","unstructured":"3 National Center for Health Statistics (1981) Plan and Operation of the Second National Health and Nutrition Examination Survey, 1976\u20131980. Vital and Health Statistics Series 1, no. 232. DHHS publication no. (PHS) 81-1317. Progress and collection procedures, no. 15 Public Health Service. Washington, DC: National Center for Health Statistics, United States Government Printing Office."},{"key":"S0007114507864828_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20864"},{"key":"S0007114507864828_ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"S0007114507864828_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601315"},{"key":"S0007114507864828_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1985.tb05437.x"},{"key":"S0007114507864828_ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110072851512"},{"key":"S0007114507864828_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/39.3.437"},{"key":"S0007114507864828_ref16","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/clinchem\/40.8.1479","article-title":"Assessment of copper nutritional status","volume":"40","author":"Milne","year":"1994","journal-title":"Clin Chem"},{"key":"S0007114507864828_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783227"},{"key":"S0007114507864828_ref5","volume-title":"Laboratory Procedures Used by the Clinical Chemistry Division, Center for Disease Control, for the Second Health and Nutrition Examination Survey (HANES II 1976\u20131980)","author":"Gunter","year":"1981"},{"key":"S0007114507864828_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6989(83)80093-9"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114507864828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T13:13:30Z","timestamp":1588079610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114507864828\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0007114507864828"],"URL":"https:\/\/doi.org\/10.1017\/s0007114507864828","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}