{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:25Z","timestamp":1761894745106},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T00:00:00Z","timestamp":1213574400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"abstract":"<jats:p>Magnesium deficiency may be induced by a diet impoverished in magnesium. This nutritional deficit promotes chronic inflammatory and oxidative stresses, hyperexcitability and, in mice, susceptibility to audiogenic seizures. Potentiation by low-magnesium concentrations of the opening of <jats:italic>N<\/jats:italic>-methyl-<jats:sc>d<\/jats:sc>-aspartate (NMDA) receptor\/calcium channel in <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic> studies, and responsiveness to magnesium of <jats:italic>in vivo<\/jats:italic> brain injury states are now well established. By contrast, little or no specific attention has been, however, paid to the <jats:italic>in vivo<\/jats:italic> NMDA receptor function\/excitability in magnesium deficiency. The present work reports for the first time that, in mice undergoing chronic nutritional deprivation in magnesium (35 <jats:italic>v.<\/jats:italic> 930 parts per million for 27\u00a0d in OF1 mice), NMDA-induced seizure threshold is significantly decreased (38\u00a0% of normal values). The attenuation in the drop of NMDA seizure threshold (percentage of reversal) was 58 and 20\u00a0% upon acute intraperitoneal administrations of magnesium chloride hexahydrate (28\u00a0mg magnesium\/kg) and the antioxidant ebselen (20\u00a0mg\/kg), respectively. In nutritionally magnesium-deprived animals, audiogenic seizures are completely prevented by these compound doses. Taken as a whole, our data emphasise that chronic magnesium deprivation in mice is a nutritional <jats:italic>in vivo<\/jats:italic> model for a lowered NMDA receptor activation threshold. This nutritional model responds remarkably to acute magnesium supply and moderately to acute antioxidant administration.<\/jats:p>","DOI":"10.1017\/s0007114508006752","type":"journal-article","created":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T05:27:03Z","timestamp":1213594023000},"page":"317-321","source":"Crossref","is-referenced-by-count":9,"title":["Threshold to <i>N<\/i>-methyl-<scp>D<\/scp>-aspartate-induced seizures in mice undergoing chronic nutritional magnesium deprivation is lowered in a way partly responsive to acute magnesium and antioxidant 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