{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:16:55Z","timestamp":1791526615260,"version":"4.3.4"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"abstract":"<jats:p>Many studies have found that<jats:italic>N<\/jats:italic>-oleyl-ethanolamine (NOE), a metabolite of<jats:italic>N<\/jats:italic>-oleyl-phosphatidylethanolamine (NOPE), and epigallocatechin-3-gallate (EGCG) inhibit food intake. The main aim of this study was to evaluate the efficacy of 2 months of administration of an oily NOPE\u2013EGCG complex (85\u00a0mg NOPE and 50\u00a0mg EGCG per capsule) and its effect on compliance with diet in healthy, overweight people. Secondary end-points of the study were to compare body composition, metabolic parameters, sensation of appetite, depressive symptoms and severity of binge eating. Using a parallel-arm, double-blind, placebo-controlled design, 138 healthy, overweight women (106) and men (thirty-two) were randomly assigned to one of two groups: (1) the treatment group (seventy-one patients: fifty-three females, eighteen males) taking two capsules per day of an oral supplement or (2) the placebo group (sixty-seven patients: fifty-three females, fourteen males). Both groups observed a 3344\u00a0kJ\/d energy restriction. All parameters were assessed both before onset and after 2 months on the supplement. Dropout was 6\u00a0% in the NOPE\u2013EGCG group and 27\u00a0% in the placebo group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). The treatment induced a significant weight reduction in both groups (\u00a0\u2212\u00a03\u00b728\u00a0kg and \u2212\u00a02\u00b767\u00a0kg in NOPE\u2013EGCG and placebo, respectively); the weight changes were not significantly different between the groups. NOPE\u2013EGCG treatment improved insulin resistance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), the sensation feelings of fullness (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), depressive symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7004) and severity of binge eating (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001).<\/jats:p>","DOI":"10.1017\/s0007114508024008","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T09:04:35Z","timestamp":1214903075000},"page":"457-464","source":"Crossref","is-referenced-by-count":37,"title":["Administration of a dietary supplement (<i>N<\/i>-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled 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