{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:35:54Z","timestamp":1790940954792,"version":"4.1.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"abstract":"<jats:p>A study was conducted evaluating the effect of long-term Cu deficiency, with or without high Mn, on growth, gene expression and Cu status of beef cattle. Twenty-one Angus calves were born to cows receiving one of the following treatments: (1) 10\u00a0mg supplemental Cu\/kg DM (+Cu); (2) no supplemental Cu and 2\u00a0mg Mo\/kg DM (\u00a0\u2212\u00a0Cu); (3) \u2212\u00a0Cu diet plus 500\u00a0mg supplemental Mn\/kg DM (\u00a0\u2212\u00a0Cu+Mn). Calves were weaned at approximately 183\u00a0d of age and individually fed throughout the growing and finishing phases. Plasma Cu was lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) in \u2212\u00a0Cu calves compared with +Cu calves while high dietary Mn further depressed (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) plasma Cu in \u2212\u00a0Cu+Mn calves<jats:italic>v.<\/jats:italic>\u2212\u00a0Cu calves. Liver Cu concentrations in +Cu calves were greater (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) than in \u2212\u00a0Cu calves, with no differences between \u2212\u00a0Cu and \u2212\u00a0Cu+Mn calves. The daily body-weight gain of +Cu calves was greater (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) than \u2212\u00a0Cu calves during the period from birth to weaning, but did not differ during the growing phase. \u2212\u00a0Cu+Mn calves gained less (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) than \u2212\u00a0Cu calves during the growing phase. DM intake was lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) in \u2212\u00a0Cu+Mn calves<jats:italic>v.<\/jats:italic>\u2212\u00a0Cu calves, and did not differ among +Cu and \u2212\u00a0Cu calves. The relative gene expression of cytochrome c oxidase in the liver was lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in \u2212\u00a0Cu calves compared with +Cu or \u2212\u00a0Cu+Mn calves. In conclusion, feeding a Cu\u00a0\u2212\u00a0deficient diet in combination with high Mn negatively affected the growth and Cu status of beef cattle.<\/jats:p>","DOI":"10.1017\/s0007114508057589","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T08:17:26Z","timestamp":1220861846000},"page":"1068-1078","source":"Crossref","is-referenced-by-count":30,"title":["The addition of high manganese to a copper-deficient diet further depresses copper status and growth of cattle"],"prefix":"10.1017","volume":"101","author":[{"given":"Stephanie L.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Ashwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon R.","family":"Legleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry W.","family":"Spears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"S0007114508057589_ref21","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-841"},{"key":"S0007114508057589_ref15","unstructured":"15 Legleiter LR (2006) The relationship between copper, manganese, and bovine brain prion proteins: implications for trace mineral nutrition and bovine spongiform encephalopathy. PhD Thesis, North Carolina State University."},{"key":"S0007114508057589_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00634.x"},{"key":"S0007114508057589_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.21"},{"key":"S0007114508057589_ref28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1096\/fasebj.22.1_supplement.443.5","article-title":"Impact of copper deficiency in cattle on proteins involved in iron metabolism","volume":"22","author":"Hansen","year":"2008","journal-title":"FASEB J"},{"key":"S0007114508057589_ref8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.001005"},{"key":"S0007114508057589_ref40","first-page":"235","volume-title":"Mineral Tolerance of Domestic Animals","year":"2005"},{"key":"S0007114508057589_ref39","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/121.3.355"},{"key":"S0007114508057589_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.5.1003"},{"key":"S0007114508057589_ref5","doi-asserted-by":"publisher","DOI":"10.2527\/1993.71102748x"},{"key":"S0007114508057589_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.010"},{"key":"S0007114508057589_ref29","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19760039"},{"key":"S0007114508057589_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.10.1223"},{"key":"S0007114508057589_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.1.14"},{"key":"S0007114508057589_ref3","first-page":"31","volume-title":"Proceedings of the Northwest Chapter of American Registry of Professional Animal Scientists Symposium: Copper and Health in Ruminants","author":"Spears","year":"1996"},{"key":"S0007114508057589_ref35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00478.2003"},{"key":"S0007114508057589_ref1","doi-asserted-by":"publisher","DOI":"10.1079\/9780851991283.0000"},{"key":"S0007114508057589_ref2","volume-title":"Nutrient Requirements of Beef Cattle","year":"1996"},{"key":"S0007114508057589_ref6","doi-asserted-by":"publisher","DOI":"10.2527\/1994.72102722x"},{"key":"S0007114508057589_ref7","first-page":"225","volume-title":"3. Spurenelement-Symposium Arsen","author":"Poole","year":"1980"},{"key":"S0007114508057589_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/00288233.1973.10421132"},{"key":"S0007114508057589_ref43","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(84)81466-6"},{"key":"S0007114508057589_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.2.416"},{"key":"S0007114508057589_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.9.e36"},{"key":"S0007114508057589_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00480.2002"},{"key":"S0007114508057589_ref13","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(76)84435-9"},{"key":"S0007114508057589_ref16","doi-asserted-by":"publisher","DOI":"10.2527\/2000.7892446x"},{"key":"S0007114508057589_ref17","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-814"},{"key":"S0007114508057589_ref18","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2006-640"},{"key":"S0007114508057589_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00332-6"},{"key":"S0007114508057589_ref20","volume-title":"The Mineral Nutrition of Livestock","author":"Underwood","year":"1981"},{"key":"S0007114508057589_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/43.2.251"},{"key":"S0007114508057589_ref23","doi-asserted-by":"publisher","DOI":"10.2527\/1997.75113057x"},{"key":"S0007114508057589_ref25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302242200"},{"key":"S0007114508057589_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.10.2048"},{"key":"S0007114508057589_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.05.003"},{"key":"S0007114508057589_ref37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2111-04.2004"},{"key":"S0007114508057589_ref41","doi-asserted-by":"publisher","DOI":"10.2527\/jas1966.252532x"},{"key":"S0007114508057589_ref42","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(91)78254-4"},{"key":"S0007114508057589_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(76)90068-2"},{"key":"S0007114508057589_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-2927(02)00079-3"},{"key":"S0007114508057589_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.03.009"},{"key":"S0007114508057589_ref14","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00036.2006"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114508057589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T04:04:26Z","timestamp":1631765066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114508057589\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,8]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,4,14]]}},"alternative-id":["S0007114508057589"],"URL":"https:\/\/doi.org\/10.1017\/s0007114508057589","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,8]]}}}