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Compared to the vehicle-injected control, the intracerebroventricular administration of WIN 55,212-2 was associated with a significant increase in food intake, whereas the administration of AM 251 caused a significant reduction in this respect. These results were accompanied by considerable reductions or increases in serotonin and acetic acid 5-hydroxy-indol levels compared to the vehicle-injected control and the baseline values for the different experimental groups studied. Intraperitoneal administration of WIN 55,212-2 at doses of 1 and 2\u00a0mg\/kg promoted hyperphagia up to 6\u00a0h after injection, whereas administration of a higher dose (5\u00a0mg\/kg) significantly inhibited food intake and motor behaviour in partially satiated rats. Administration of any of the AM 251 doses studied (0\u00b75, 1, 2, 5\u00a0mg\/kg) led to a significant decrease in the amount of food ingested from 2\u00a0h after the injection, compared to the vehicle-injected control group, with the most striking effect being observed when the 5\u00a0mg\/kg dose was injected.<\/jats:p>","DOI":"10.1017\/s0007114508083530","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T10:43:21Z","timestamp":1235731401000},"page":"1569-1578","source":"Crossref","is-referenced-by-count":25,"title":["Influence of intracerebroventricular or intraperitoneal administration of cannabinoid receptor agonist (WIN 55,212-2) and inverse agonist (AM 251) on the regulation of food intake and hypothalamic serotonin 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