{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:37:09Z","timestamp":1774528629777,"version":"3.50.1"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"abstract":"<jats:p>Efforts to increase \u03b2-carotene in cassava have been successful, but the ability of high-\u03b2-carotene cassava to prevent vitamin A deficiency has not been determined. Two studies investigated the bioefficacy of provitamin A in cassava and compared the effects of carotenoid content and variety on vitamin A status in vitamin A-depleted Mongolian gerbils (<jats:italic>Meriones unguiculatus<\/jats:italic>). Gerbils were fed a vitamin A-free diet 4 weeks prior to treatment. In Expt 1, treatments (ten gerbils per group) included 45\u00a0% high-\u03b2-carotene cassava, \u03b2-carotene and vitamin A supplements (intake matched to high-\u03b2-carotene cassava group), and oil control. In Expt 2, gerbils were fed cassava feeds with 1\u00b78 or 4\u00b73\u00a0nmol provitamin A\/g prepared with two varieties. Gerbils were killed after 4 weeks. For Expt 1, liver vitamin A was higher (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in the vitamin A (1\u00b745 (<jats:sc>sd<\/jats:sc> 0\u00b723) \u03bcmol\/liver), lower in the control (0\u00b743 (<jats:sc>sd<\/jats:sc> 0\u00b710) \u03bcmol\/liver), but did not differ from the \u03b2-carotene group (0\u00b777 (<jats:sc>sd<\/jats:sc> 0\u00b712) \u03bcmol\/liver) when compared with the high-\u03b2-carotene cassava group (0\u00b769 (<jats:sc>sd<\/jats:sc> 0\u00b720) \u03bcmol\/liver). The bioconversion factor was 3\u00b77\u00a0\u03bcg \u03b2-carotene to 1\u00a0\u03bcg retinol (2\u00a0mol:1\u00a0mol), despite 48\u00a0% <jats:italic>cis<\/jats:italic>-\u03b2-carotene [(<jats:italic>Z<\/jats:italic>)-\u03b2-carotene] composition in cassava. In Expt 2, cassava feed with 4\u00b73\u00a0nmol provitamin A\/g maintained vitamin A status. No effect of cassava variety was observed. Serum retinol concentrations did not differ. \u03b2-Carotene was detected in livers of gerbils receiving cassava and supplements, but the <jats:italic>cis<\/jats:italic>-to-<jats:italic>trans<\/jats:italic> ratio in liver differed from intake. Biofortified cassava adequately maintained vitamin A status and was as efficacious as \u03b2-carotene supplementation in the gerbil model.<\/jats:p>","DOI":"10.1017\/s0007114508184720","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T10:02:13Z","timestamp":1231840933000},"page":"342-349","source":"Crossref","is-referenced-by-count":30,"title":["Cassava with enhanced \u03b2-carotene maintains adequate vitamin A status in Mongolian gerbils (<i>Meriones unguiculatus<\/i>) despite substantial <i>cis<\/i>-isomer content"],"prefix":"10.1017","volume":"102","author":[{"given":"Julie A.","family":"Howe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bussie","family":"Maziya-Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry A.","family":"Tanumihardjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"S0007114508184720_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2709"},{"key":"S0007114508184720_ref22","first-page":"1","volume-title":"The Retinoids","volume":"2","author":"Goodman","year":"1984"},{"key":"S0007114508184720_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2562"},{"key":"S0007114508184720_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00494-7"},{"key":"S0007114508184720_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(00)00122-4"},{"key":"S0007114508184720_ref4","first-page":"325","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","year":"2000"},{"key":"S0007114508184720_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.5.949"},{"key":"S0007114508184720_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"S0007114508184720_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.12.2271"},{"key":"S0007114508184720_ref6","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.72.1.40"},{"key":"S0007114508184720_ref28","doi-asserted-by":"publisher","DOI":"10.1021\/jf062256f"},{"key":"S0007114508184720_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(97)00113-9"},{"key":"S0007114508184720_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2647"},{"key":"S0007114508184720_ref33","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061562"},{"key":"S0007114508184720_ref1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1002962108315"},{"key":"S0007114508184720_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.2.177"},{"key":"S0007114508184720_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60015-1"},{"key":"S0007114508184720_ref39","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508944123"},{"key":"S0007114508184720_ref29","doi-asserted-by":"publisher","DOI":"10.1021\/jf020109l"},{"key":"S0007114508184720_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.3.623"},{"key":"S0007114508184720_ref16","doi-asserted-by":"publisher","DOI":"10.1021\/jf021245t"},{"key":"S0007114508184720_ref14","doi-asserted-by":"publisher","DOI":"10.1021\/jf040028k"},{"key":"S0007114508184720_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.03.024"},{"key":"S0007114508184720_ref9","first-page":"53","article-title":"Effect of dietary-fat on absorption of beta-carotene from green leafy vegetables in children","volume":"71","author":"Jayarajan","year":"1980","journal-title":"Indian J Med Res"},{"key":"S0007114508184720_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.4.665"},{"key":"S0007114508184720_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2622"},{"key":"S0007114508184720_ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2008.00064.x"},{"key":"S0007114508184720_ref41","volume-title":"Vitamin A Requirement of Human Adults. 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