{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:24:16Z","timestamp":1777541056321,"version":"3.51.4"},"reference-count":90,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>We investigated whether the hypolipidaemic effect of fenofibrate and fasting observed in most omnivorous mammals may also apply to herbivorous fish. Grass carp (<jats:italic>Ctenopharyngodon idella<\/jats:italic>) fed a high-fat (8\u00a0%) diet exhibited a marked increase in blood lipids and body fat after 6 weeks. They were then treated with fenofibrate (100\u00a0mg\/kg body weight) in the same high-fat diet for 2 weeks, followed by fasting for 1 week. Plasma lipid concentration, body fat amount, fatty acid composition, plasma thiobarbituric acid-reactive substances and some parameters related to hepatic fatty acid oxidation were measured, and liver samples were stained for histological examination. Fenofibrate treatment decreased TAG and cholesterol concentrations in plasma, total lipids of the whole body and liver, and EPA and DHA contents in tissues. Further, a mobilisation of mesenteric fat concomitant with an increase in hepatic peroxisomal fatty acid oxidation and lipid peroxidation was observed. Compared with fenofibrate treatment, fasting decreased body weight and plasma TAG, but not plasma cholesterol. It also reduced the fat content of the whole body and increased the EPA and DHA contents in the liver and other tissues. Fatty acid oxidation was stimulated by fasting in mitochondria, but not in peroxisomes. These data suggest that fenofibrate and fasting regulate the lipid metabolism in grass carp through different metabolic pathways. The grass carp is moderately responsive to a fibrate derivative in comparison with the well-known excess responsiveness of the rat model, and so it could be used for the study of lipid abnormalities as a herbivorous model.<\/jats:p>","DOI":"10.1017\/s0007114508986840","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T13:58:04Z","timestamp":1209477484000},"page":"1200-1212","source":"Crossref","is-referenced-by-count":38,"title":["Hypolipidaemic effects of fenofibrate and fasting in the herbivorous grass carp (<i>Ctenopharyngodon idella<\/i>) fed a high-fat diet"],"prefix":"10.1017","volume":"100","author":[{"given":"Zhen-Yu","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Clouet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Degrace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livar","family":"Fr\u00f8yland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Xia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"S0007114508986840_ref89","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(94)90002-7"},{"key":"S0007114508986840_ref87","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.9.1213"},{"key":"S0007114508986840_ref84","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(91)90389-Z"},{"key":"S0007114508986840_ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2004.10.008"},{"key":"S0007114508986840_ref81","doi-asserted-by":"publisher","DOI":"10.2337\/diab.36.2.169"},{"key":"S0007114508986840_ref80","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(94)00322-F"},{"key":"S0007114508986840_ref79","doi-asserted-by":"publisher","DOI":"10.1007\/BF02668066"},{"key":"S0007114508986840_ref78","doi-asserted-by":"publisher","DOI":"10.1042\/bj3540189"},{"key":"S0007114508986840_ref77","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90528-5"},{"key":"S0007114508986840_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(85)90005-9"},{"key":"S0007114508986840_ref68","doi-asserted-by":"publisher","DOI":"10.1007\/BF02523828"},{"key":"S0007114508986840_ref67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-2275(20)41315-X","article-title":"Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats","volume":"34","author":"Willumsen","year":"1993","journal-title":"J Lipid Res"},{"key":"S0007114508986840_ref65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118703"},{"key":"S0007114508986840_ref62","doi-asserted-by":"publisher","DOI":"10.5551\/jat1994.3.81"},{"key":"S0007114508986840_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(97)00035-5"},{"key":"S0007114508986840_ref59","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1996.0046"},{"key":"S0007114508986840_ref56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.25713"},{"key":"S0007114508986840_ref55","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.3.286"},{"key":"S0007114508986840_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(92)90595-H"},{"key":"S0007114508986840_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00622-0"},{"key":"S0007114508986840_ref47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801548"},{"key":"S0007114508986840_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00040-X"},{"key":"S0007114508986840_ref44","first-page":"77","article-title":"The change of blood lipid indexed after fed high-fat diet in grass carp (article in Chinese)","volume":"43","author":"Du","year":"2004","journal-title":"Acta Sci Natur Univ Sunyatseni"},{"key":"S0007114508986840_ref42","first-page":"61","volume-title":"Application of Nuclear Technology in Biology","author":"Chen","year":"1992"},{"key":"S0007114508986840_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)91512-2"},{"key":"S0007114508986840_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(94)00403-B"},{"key":"S0007114508986840_ref38","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0021-9258(18)69497-9","article-title":"A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine","volume":"235","author":"Weissbach","year":"1960","journal-title":"J Biol Chem"},{"key":"S0007114508986840_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90442-7"},{"key":"S0007114508986840_ref36","doi-asserted-by":"publisher","DOI":"10.1042\/bj2630867"},{"key":"S0007114508986840_ref35","volume-title":"Theory and Practice of Histopathological Techniques","author":"Bancroft","year":"1977"},{"key":"S0007114508986840_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(03)00537-4"},{"key":"S0007114508986840_ref32","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/clinchem\/44.12.2499","article-title":"Comparison of two homogeneous assays with a precipitation method and an ultracentrifugation method for the measurement of HDL-cholesterol","volume":"44","author":"Arranz-Pena","year":"1998","journal-title":"Clin Chem"},{"key":"S0007114508986840_ref31","first-page":"S260","article-title":"Homogeneous assays of serum LDL-cholesterol on an automatic analyzer","volume":"43","author":"Nakamura","year":"1997","journal-title":"Clin Chem"},{"key":"S0007114508986840_ref30","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/clinchem\/19.12.1350","article-title":"Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum","volume":"19","author":"Richmond","year":"1973","journal-title":"Clin Chem"},{"key":"S0007114508986840_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(97)00226-7"},{"key":"S0007114508986840_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2007.00507.x"},{"key":"S0007114508986840_ref25","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061733"},{"key":"S0007114508986840_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2095.2004.00333.x"},{"key":"S0007114508986840_ref22","first-page":"2020","article-title":"Food deprivation modifies fatty acid partitioning and \u03b2-oxidation capacity in rat liver","volume":"126","author":"Andriamampandry","year":"1996","journal-title":"J Nutr"},{"key":"S0007114508986840_ref19","first-page":"989","article-title":"Effect of moderate semi-starvation on plasma lipids","volume":"14","author":"Vaisman","year":"1990","journal-title":"Int J Obes"},{"key":"S0007114508986840_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.11.2005"},{"key":"S0007114508986840_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124316"},{"key":"S0007114508986840_ref14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6223"},{"key":"S0007114508986840_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02146-9"},{"key":"S0007114508986840_ref10","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0022-2275(20)37159-5","article-title":"Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism","volume":"38","author":"Fr\u00f8yland","year":"1997","journal-title":"J Lipid Res"},{"key":"S0007114508986840_ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118687"},{"key":"S0007114508986840_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000127122.22685.0A"},{"key":"S0007114508986840_ref7","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0871"},{"key":"S0007114508986840_ref6","first-page":"2202","article-title":"Regulation of lipid metabolism and gene expression by fenofibrate in hamsters","volume":"1533","author":"Guo","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"S0007114508986840_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2002.tb00098.x"},{"key":"S0007114508986840_ref53","first-page":"5A","article-title":"Cholesterol and lipids in the risk of coronary artery disease \u2013 the Framingham Heart Study","volume":"4","author":"Castelli","year":"1988","journal-title":"Can J Cardiol"},{"key":"S0007114508986840_ref20","first-page":"E541","article-title":"Regulation of lipid metabolism in adipose tissue during early starvation","volume":"271","author":"Samra","year":"1996","journal-title":"Am J Physiol"},{"key":"S0007114508986840_ref5","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.627"},{"key":"S0007114508986840_ref70","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1016\/S0021-9258(17)30051-0","article-title":"Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats","volume":"254","author":"Mannaerts","year":"1979","journal-title":"J Biol Chem"},{"key":"S0007114508986840_ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12622"},{"key":"S0007114508986840_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0044-8486(92)90115-2"},{"key":"S0007114508986840_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(86)90180-3"},{"key":"S0007114508986840_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(83)90064-4"},{"key":"S0007114508986840_ref58","first-page":"133","article-title":"Effects of starvation on blood biochemical parameters in Japanese sea bass (Lateolabrax japonicus) (article in Chinese)","volume":"9","author":"Qian","year":"2002","journal-title":"J Fish Sci China"},{"key":"S0007114508986840_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(97)00175-0"},{"key":"S0007114508986840_ref1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.12.3486"},{"key":"S0007114508986840_ref28","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"S0007114508986840_ref76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.29.040189.001045"},{"key":"S0007114508986840_ref29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1128\/JB.98.3.1063-1068.1969","article-title":"\u03b1-Glycerophosphate oxidase in Streptococcus faecium F 24","volume":"98","author":"Koditschek","year":"1969","journal-title":"J Bacteriol"},{"key":"S0007114508986840_ref86","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(93)90086-8"},{"key":"S0007114508986840_ref82","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(03)00002-4"},{"key":"S0007114508986840_ref73","first-page":"181","volume-title":"Fish Nutrition","author":"Sargent","year":"2002"},{"key":"S0007114508986840_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)88891-4"},{"key":"S0007114508986840_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(00)00493-2"},{"key":"S0007114508986840_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315136"},{"key":"S0007114508986840_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF03179875"},{"key":"S0007114508986840_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02023-8"},{"key":"S0007114508986840_ref61","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611391200"},{"key":"S0007114508986840_ref88","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(87)90151-X"},{"key":"S0007114508986840_ref66","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.9.2131"},{"key":"S0007114508986840_ref33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/clinchem\/29.3.415","article-title":"Some considerations of methodology and standardization of apolipoprotein A-I immunoassays","volume":"29","author":"Steinberg","year":"1983","journal-title":"Clin Chem"},{"key":"S0007114508986840_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"key":"S0007114508986840_ref90","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00004-5"},{"key":"S0007114508986840_ref75","doi-asserted-by":"publisher","DOI":"10.3109\/03602538708994130"},{"key":"S0007114508986840_ref74","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.1.43"},{"key":"S0007114508986840_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(81)90282-4"},{"key":"S0007114508986840_ref64","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1268"},{"key":"S0007114508986840_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02150-6"},{"key":"S0007114508986840_ref63","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.10.8458"},{"key":"S0007114508986840_ref52","first-page":"542","article-title":"The effects of three oil sources and two anti-fatty liver factors on the growth, nutrient compostion and serum biochemical indexes on Lateolabrax japonicus (article in Chinese)","volume":"26","author":"Du","year":"2002","journal-title":"J Fish China"},{"key":"S0007114508986840_ref3","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000372"},{"key":"S0007114508986840_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.2.E270"},{"key":"S0007114508986840_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(96)05852-2"},{"key":"S0007114508986840_ref85","doi-asserted-by":"publisher","DOI":"10.3109\/10408448309029317"},{"key":"S0007114508986840_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-004-1306-3"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114508986840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T03:53:15Z","timestamp":1631159595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114508986840\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0007114508986840"],"URL":"https:\/\/doi.org\/10.1017\/s0007114508986840","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}