{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:07:11Z","timestamp":1770070031231,"version":"3.49.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Aspirin causes gastroduodenal ulcers and complications. Food bioactive compounds could exert beneficial effects in the gastrointestinal tract. We evaluated whether apple polyphenol extract (APE) reduced aspirin-induced injury to the rat gastric mucosa. Rats were treated with APE (10<jats:sup>\u2212\u00a04<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> catechin equivalent) before oral aspirin (200\u00a0mg\/kg). Cyclo-oxygenase-2 (COX-2), transforming growth factor-\u03b1 (TGF\u03b1) and heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) mRNA and protein expression were assessed by RT-PCR and Western blot analysis, respectively; malondialdehyde (MDA) was determined by HPLC; gastric secretion was evaluated in pylorus-ligated rats. APE decreased acute and chronic aspirin injury both macroscopically and microscopically (approximately 50\u00a0% decrease in lesion score; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Aspirin up-regulated mRNA and protein expression of COX-2 and HB-EGF, but not of TGF\u03b1; APE reduced aspirin-induced mRNA and protein over-expression of COX-2 and HB-EGF; aspirin significantly increased gastric MDA and this effect was counteracted by APE pre-treatment. APE did not significantly affect gastric acid secretion. In conclusion, APE reduces aspirin-induced gastric injury independently of acid inhibition. We speculate that APE might be of therapeutic use in the prophylaxis of aspirin-related gastropathy.<\/jats:p>","DOI":"10.1017\/s0007114508988747","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T08:33:29Z","timestamp":1210926809000},"page":"1228-1236","source":"Crossref","is-referenced-by-count":44,"title":["Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric 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