{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:09:52Z","timestamp":1769454592975,"version":"3.49.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2009,9,28]]},"abstract":"<jats:p>Recommendations for vitamin A intake are based on maintaining liver stores of \u2265\u00a00\u00b7070\u00a0\u03bcmol\/g, which is sufficient to maintain normal vision. We propose that higher levels may be required to maintain normal immune function. To test this hypothesis, we conducted an 8-week residential study among thirty-six healthy Bangladeshi men with low vitamin A stores. Subjects were randomised to receive vitamin A (240\u00a0mg in four doses) or placebo during study weeks 2 and 3. Vitamin A stores were estimated by isotopic dilution at week 8. Total T-cells, the naive T-cells:memory T-cells ratio and mitogen-induced lymphocyte proliferation were positively and significantly correlated with vitamin A stores (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Mitogen-stimulated IL-2, IL-4 and TNF\u03b1 increased significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) in the vitamin A but not placebo group after supplementation, while IL-10 production was significantly and negatively correlated with vitamin A stores (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Segmented linear regression analysis revealed that naive T-cell counts and T-cell blastogenesis were positively associated with vitamin A stores above but not below 0\u00b7070\u00a0\u03bcmol\/g liver. These data show that increasing vitamin A stores above the level that maintains normal vision enhances some measures of T-cell-mediated immunity, suggesting a difference in requirements for maintaining vision and immune function.<\/jats:p>","DOI":"10.1017\/s0007114509316165","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T08:20:33Z","timestamp":1238574033000},"page":"797-802","source":"Crossref","is-referenced-by-count":18,"title":["Vitamin A status is associated with T-cell responses in Bangladeshi men"],"prefix":"10.1017","volume":"102","author":[{"given":"Shaikh M.","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie J.","family":"Haskell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubhana","family":"Raqib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles 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