{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:52:09Z","timestamp":1790545929197,"version":"4.1.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2009,11,28]]},"abstract":"<jats:p>Previously we have examined the effects of diets deficient in folic acid (\u00a0\u2212\u00a0F) or folate deficient with low methionine and choline (\u00a0\u2212\u00a0F LM LC) on the relative abundance of soluble proteins in the liver of the pregnant rat. In the present study we report the corresponding changes in the fetal liver at day 21 of gestation. The abundance of eighteen proteins increased when dams were fed the \u2212\u00a0F diet. When dams were fed the \u2212\u00a0F LM LC diet, thirty-three proteins increased and eight decreased. Many of the differentially abundant proteins in the fetal liver could be classified into the same functional groups as those previously identified in the maternal liver, namely protein synthesis, metabolism, lipid metabolism and proteins associated with the cytoskeleton and endoplasmic reticulum. The pattern was consistent with reduced cell proliferation in the \u2212\u00a0F LM LC group but not in the \u2212\u00a0F group. Metabolic enzymes associated with lipid metabolism changed in both the \u2212\u00a0F and \u2212\u00a0F LM LC groups. The mRNA for carnitine palmitoyl transferase were up-regulated and CD36 (fatty acid translocase) down-regulated in the \u2212\u00a0F group, suggesting increased mitochondrial oxidation of fatty acids as an indirect response to altered maternal lipid metabolism. In the \u2212\u00a0F LM LC group the mRNA for acetyl CoA carboxylase was down-regulated, suggesting reduced fatty acid synthesis. The mRNA for transcriptional regulators including PPAR\u03b1 and sterol response element-binding protein-1c were unchanged. These results suggest that an adequate supply of folic acid and the related methyl donors may benefit fetal development directly by improving lipid metabolism in fetal as well as maternal tissues.<\/jats:p>","DOI":"10.1017\/s0007114509990389","type":"journal-article","created":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T10:10:06Z","timestamp":1246443006000},"page":"1445-1452","source":"Crossref","is-referenced-by-count":16,"title":["Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat"],"prefix":"10.1017","volume":"102","author":[{"given":"Christopher J.","family":"McNeil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry 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