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The former over-optimistic attitude has clearly called for a more realistic assessment of the benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due to saturation through their normal diet, there could be a large subpopulation with a potential health problem that remains uninvestigated. The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials.<\/jats:p>","DOI":"10.1017\/s0007114509993229","type":"journal-article","created":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T11:23:17Z","timestamp":1260876197000},"page":"1251-1259","source":"Crossref","is-referenced-by-count":163,"title":["Is vitamin C supplementation beneficial? 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