{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:04:59Z","timestamp":1759529099406},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2010,7,14]]},"abstract":"<jats:p>Diets that ameliorate the adverse effects of uric acid (UA) on renal damage deserve attention. The effects of casein or soya protein combined with palm or safflower-seed oil on various serum parameters and renal histology were investigated on hyperuricaemic rats. Male Wistar rats administered with oxonic acid and UA to induce hyperuricaemia were fed with casein or soya protein plus palm- or safflower-seed oil-supplemented diets. Normal rats and hyperuricaemic rats with or without allopurinol treatment (150\u00a0mg\/l in drinking water) were fed with casein plus maize oil-supplemented diets. After 8 weeks, allopurinol treatment and soya protein plus safflower-seed oil-supplemented diet significantly decreased serum UA in hyperuricaemic rats (one-way ANOVA;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). In addition, soya protein and casein attenuated hyperuricaemia-induced decreases in serum albumin and insulin, respectively (two-way ANOVA;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Safflower-seed oil significantly decreased serum TAG and UA, whereas palm oil significantly increased serum cholesterol, TAG, blood urea N and creatinine. However, soya protein significantly decreased renal NO and nitrotyrosine and palm oil significantly decreased renal nitrotyrosine, TNF-\u03b1 and interferon-\u03b3 and increased renal transforming growth factor-\u03b2. Casein with safflower-seed oil significantly attenuated renal tubulointerstitial nephritis, crystals and fibrosis. Comparing casein<jats:italic>v.<\/jats:italic>soya protein combined with palm or safflower-seed oil, the results support that casein with safflower-seed oil may be effective in attenuating hyperuricaemia-associated renal damage, while soya protein with safflower-seed oil may be beneficial in lowering serum UA and TAG.<\/jats:p>","DOI":"10.1017\/s0007114510000310","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T10:57:00Z","timestamp":1267441020000},"page":"67-75","source":"Crossref","is-referenced-by-count":14,"title":["Relative efficacy of casein or soya protein combined with palm or safflower-seed oil on hyperuricaemia in rats"],"prefix":"10.1017","volume":"104","author":[{"given":"Hui-Chen","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Horng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hue-Ying","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Hu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"key":"S0007114510000310_ref29","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/jn\/132.9.2562","article-title":"A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome","volume":"132","author":"Tovar","year":"2002","journal-title":"J Nutr"},{"key":"S0007114510000310_ref17","first-page":"1350","article-title":"Gout, diet, and the insulin resistance syndrome","volume":"29","author":"Fam","year":"2002","journal-title":"J Rheumatol"},{"key":"S0007114510000310_ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000066303"},{"key":"S0007114510000310_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)00934-5"},{"key":"S0007114510000310_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02963-1"},{"key":"S0007114510000310_ref30","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2065"},{"key":"S0007114510000310_ref27","first-page":"656","article-title":"Allopurinol-induced DRESS syndrome","volume":"7","author":"Markel","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"S0007114510000310_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00273.x"},{"key":"S0007114510000310_ref23","first-page":"11","article-title":"Oil content and fatty acid composition of some safflower (Carthamus tinctorius L.) varieties sown in spring and winter","volume":"1","author":"Cosge","year":"2007","journal-title":"Int J Natural Eng Sci"},{"key":"S0007114510000310_ref9","first-page":"149","article-title":"Pharmacological treatment of acute and chronic hyperuricemia in kidney diseased patients","volume":"147","author":"Bellinghieri","year":"2005","journal-title":"Contrib Nephrol"},{"key":"S0007114510000310_ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00835.x"},{"key":"S0007114510000310_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.01.002"},{"key":"S0007114510000310_ref15","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2001000600004"},{"key":"S0007114510000310_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/hy1101.092839"},{"key":"S0007114510000310_ref31","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1093\/jn\/134.8.1874","article-title":"Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy","volume":"134","author":"Teixeira","year":"2004","journal-title":"J Nutr"},{"key":"S0007114510000310_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.10.001"},{"key":"S0007114510000310_ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048015"},{"key":"S0007114510000310_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00074.x"},{"key":"S0007114510000310_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.09.002"},{"key":"S0007114510000310_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2005.00621.x"},{"key":"S0007114510000310_ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-008-3211-4"},{"key":"S0007114510000310_ref33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1079\/BJN20061751","article-title":"Effects of various soya protein hydrolysates on lipid profile, blood pressure and renal function in five-sixths nephrectomized rats","volume":"96","author":"Chen","year":"2006","journal-title":"Br J Nutr"},{"key":"S0007114510000310_ref18","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/jn\/134.6.1504","article-title":"Dietary soy protein attenuates renal disease progression after 1 and 3 weeks in Han:SPRD-cy weanling rats","volume":"134","author":"Fair","year":"2004","journal-title":"J Nutr"},{"key":"S0007114510000310_ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-1001-4"},{"key":"S0007114510000310_ref34","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90385.2008"},{"key":"S0007114510000310_ref10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00350106"},{"key":"S0007114510000310_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00270.x"},{"key":"S0007114510000310_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken070"},{"key":"S0007114510000310_ref22","first-page":"325","article-title":"Effect of palm oil on blood pressure, endothelial function and oxidative stress","volume":"14","author":"Bayorh","year":"2005","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0007114510000310_ref14","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129031"},{"key":"S0007114510000310_ref2","first-page":"285","article-title":"High prevalence of hyperuricemia in elderly Taiwanese","volume":"14","author":"Lee","year":"2005","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0007114510000310_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601688"},{"key":"S0007114510000310_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32830e4945"},{"key":"S0007114510000310_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.119"},{"key":"S0007114510000310_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2004.12.003"},{"key":"S0007114510000310_ref1","first-page":"1640","article-title":"Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993\u201396)","volume":"28","author":"Chang","year":"2001","journal-title":"J Rheumatol"},{"key":"S0007114510000310_ref3","first-page":"259","article-title":"The serum uric acid and related cardiovascular risk factors in south Taiwan","volume":"36","author":"Huang","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"S0007114510000310_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.04.009"},{"key":"S0007114510000310_ref36","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021828132707"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114510000310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T14:15:53Z","timestamp":1711289753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114510000310\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7,14]]}},"alternative-id":["S0007114510000310"],"URL":"https:\/\/doi.org\/10.1017\/s0007114510000310","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,1]]}}}