{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:50:35Z","timestamp":1763535035110},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T00:00:00Z","timestamp":1269561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2010,9,14]]},"abstract":"<jats:p>Extracts from or derivatives of<jats:italic>Phaseolus vulgaris<\/jats:italic>beans reduce body weight and food intake, including highly palatable foods and fluids, in multiple rodent models of overeating and obesity. The present study was designed to assess whether a standardised<jats:italic>P. vulgaris<\/jats:italic>dry extract was effective in reducing also the operant self-administration of a chocolate-flavoured beverage. To this end, rats were initially trained to lever-press for a chocolate-flavoured beverage under a fixed ratio 10 schedule of reinforcement in daily 60\u00a0min sessions. Once lever-responding reached stable levels, the effect of a<jats:italic>P. vulgaris<\/jats:italic>dry extract on the number of lever-responses for the chocolate-flavoured beverage was determined. Pretreatment with 50, 200 and 500\u00a0mg (intragastric)<jats:italic>P. vulgaris<\/jats:italic>dry extract per kg produced an approximate 15, 35 and 40\u00a0% reduction, respectively, in lever-responding for the chocolate-flavoured beverage. These results indicate the capacity of a<jats:italic>P. vulgaris<\/jats:italic>preparation to reduce the reinforcing properties of a highly palatable fluid in rats.<\/jats:p>","DOI":"10.1017\/s0007114510001017","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T09:50:54Z","timestamp":1269597054000},"page":"624-628","source":"Crossref","is-referenced-by-count":18,"title":["Reducing effect of a<i>Phaseolus vulgaris<\/i>dry extract on operant self-administration of a chocolate-flavoured beverage in rats"],"prefix":"10.1017","volume":"104","author":[{"given":"Paola","family":"Maccioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Riva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Morazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Bombardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Luigi","family":"Gessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro A. 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