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Three hundred and twenty 1-d-old broiler chicks were allotted into four treatment groups and fed on a control diet (30\u00a0mg\/kg<jats:sc>dl<\/jats:sc>-\u03b1-TOA) or diets containing 10, 30, 50\u00a0mg\/kg<jats:sc>d<\/jats:sc>-\u03b1-TOS. Half of the birds from each treatment group were challenged with 0\u00b79\u00a0% NaCl solution or LPS (250\u00a0\u03bcg\/kg body weight) at 16, 18 and 20\u00a0d of age. The results indicated that the pretreatment of birds with 50\u00a0mg\/kg<jats:sc>d<\/jats:sc>-\u03b1-TOS markedly reduced serum PGE<jats:sub>2<\/jats:sub>secretion and increased the concentrations of serum or hepatic \u03b1-TOH. When LPS-challenged birds were pretreated with 30 or 50\u00a0mg\/kg<jats:sc>d<\/jats:sc>-\u03b1-TOS, the increases of plasma and splenic concentrations of interferon-\u03b3, IL-1\u03b2, IL-2, IL-6, IL-4 and IL-10 were dramatically attenuated. Also, a significant decrease of hepatic reactive oxygen species (ROS) and hepatic or splenic phosphokinase C (PKC) activities was found in birds pretreated with 30 or 50\u00a0mg\/kg<jats:sc>d<\/jats:sc>-\u03b1-TOS. Furthermore,<jats:sc>d<\/jats:sc>-\u03b1-TOS inhibited the activation of NF-\u03baB by preventing the degradation of inhibitory-\u03baB\u03b1. In conclusion, D-\u03b1-TOS is able to prevent LPS-induced inflammation response<jats:italic>in vivo.<\/jats:italic>The beneficial effect may depend on suppressing the secretion of various plasma and splenic inflammatory mediators through inhibiting NF-\u03baB activation and by blocking ROS signalling, in which PKC may play an assistant role.<\/jats:p>","DOI":"10.1017\/s0007114510002801","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T11:07:22Z","timestamp":1283339242000},"page":"1796-1805","source":"Crossref","is-referenced-by-count":33,"title":["Dietary<i>RRR<\/i>-\u03b1-tocopherol succinate attenuates lipopolysaccharide-induced inflammatory cytokines secretion in broiler 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