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We have also shown that dietary calcium phosphate inhibits haemin-induced promotion and normalises faecal lipoperoxides and cytotoxicity. Unexpectedly, high-calcium phosphate control diet-fed rats had more preneoplastic lesions in the colon than low-Ca control diet-fed rats. The present study was designed to find a Ca supplementation with no adverse effect, by testing several doses and types of Ca salts. One<jats:italic>in vitro<\/jats:italic>study and two short-term studies in rats identified calcium carbonate as the most effective Ca salt to bind haem<jats:italic>in vitro<\/jats:italic>and to decrease faecal biomarkers previously associated with increased carcinogenesis: faecal water cytotoxicity and thiobarbituric acid-reactive substances. A long-term carcinogenesis study in dimethylhydrazine-injected rats demonstrated that a diet containing 100\u00a0\u03bcmol\/g calcium carbonate did not promote ACF, in contrast with a previously tested calcium phosphate diet. The results suggest that calcium carbonate, and not calcium phosphate, should be used to reduce haem-associated colorectal cancer risk in meat eaters. They support the concept that the nature of the associated anion to a protective metal ion is important for chemoprevention.<\/jats:p>","DOI":"10.1017\/s0007114510003624","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T11:15:48Z","timestamp":1291720548000},"page":"384-392","source":"Crossref","is-referenced-by-count":19,"title":["Calcium carbonate suppresses haem toxicity markers without calcium phosphate side effects on colon carcinogenesis"],"prefix":"10.1017","volume":"105","author":[{"given":"Ossama","family":"Allam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Bahuaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylviane","family":"Tach\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Naud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis E.","family":"Corpet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice H. 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