{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:11:21Z","timestamp":1770340281726,"version":"3.49.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2011,4,28]]},"abstract":"<jats:p>The present study investigates whether the replacement of dietary casein by soya protein isolate could be able to improve and\/or even revert the morphological and metabolic abnormalities underlying the adipose tissue dysfunction of dyslipidaemic rats chronically fed (8 months) a sucrose-rich (62\u00b75\u00a0%) diet (SRD). For this purpose, Wistar rats were fed a SRD for 4 months. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein, casein, was substituted by soya. The control group received a diet in which the source of carbohydrate was maize starch. Compared with the SRD-fed group, the results showed that: (1) soya protein decreased body-weight gain, limited the accretion of visceral adiposity and decreased adipose tissue cell volume without changes in total cell number; (2) soya protein increased the protein mass expression of PPAR\u03b3, which was significantly reduced in the fat pad of the SRD-fed rats; (3) the activity of the enzymes involved in the <jats:italic>de novo<\/jats:italic> lipogenesis of adipose tissue was significantly decreased\/normalised; (4) soya protein corrected the inhibitory effect of SRD upon the anti-lipolytic action of insulin, reduced basal lipolysis and normalised the protein mass expression of GLUT-4. Dyslipidaemia, glucose homeostasis and plasma leptin levels returned to control values. The present study provides data showing the beneficial effects of soya protein to improve and\/or revert the adipose tissue dysfunction of a dyslipidaemic insulin-resistant rat model and suggests that soya could maintain the functionality of the adipose tissue\u2013liver axis improving\/reverting lipotoxicity.<\/jats:p>","DOI":"10.1017\/s0007114510004915","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T09:40:15Z","timestamp":1291196415000},"page":"1188-1198","source":"Crossref","is-referenced-by-count":16,"title":["Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet"],"prefix":"10.1017","volume":"105","author":[{"given":"Mar\u00eda E.","family":"Oliva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dante","family":"Selenscig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"D'Alessandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Chicco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda B.","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"S0007114510004915_ref39","doi-asserted-by":"publisher","DOI":"10.1159\/000100820"},{"key":"S0007114510004915_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1238"},{"key":"S0007114510004915_ref35","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1550217"},{"key":"S0007114510004915_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.2.352"},{"key":"S0007114510004915_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.09.003"},{"key":"S0007114510004915_ref27","doi-asserted-by":"publisher","DOI":"10.1021\/jf072611h"},{"key":"S0007114510004915_ref26","first-page":"339","volume-title":"Statistical Methods","author":"Snedecor","year":"1967"},{"key":"S0007114510004915_ref22","first-page":"E930","article-title":"Lipoprotein lipase and hormona-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy","volume":"266","author":"Martin Hidalgo","year":"1994","journal-title":"Am J Physiol"},{"key":"S0007114510004915_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(72)90247-4"},{"key":"S0007114510004915_ref19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.5.1255"},{"key":"S0007114510004915_ref18","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300190-JLR200"},{"key":"S0007114510004915_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.11.005"},{"key":"S0007114510004915_ref10","first-page":"R486","article-title":"Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats","volume":"289","author":"Rossi","year":"2005","journal-title":"Am J Physiol"},{"key":"S0007114510004915_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.04.006"},{"key":"S0007114510004915_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508159013"},{"key":"S0007114510004915_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.10.087"},{"key":"S0007114510004915_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.3.462"},{"key":"S0007114510004915_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00230-6"},{"key":"S0007114510004915_ref4","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500067-JLR200"},{"key":"S0007114510004915_ref3","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4.72"},{"key":"S0007114510004915_ref2","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2007.jun.S64-S68"},{"key":"S0007114510004915_ref1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1195"},{"key":"S0007114510004915_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.6.1077"},{"key":"S0007114510004915_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.06.012"},{"key":"S0007114510004915_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.2.380"},{"key":"S0007114510004915_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(98)00191-2"},{"key":"S0007114510004915_ref15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.5.2109"},{"key":"S0007114510004915_ref14","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-10-1375"},{"key":"S0007114510004915_ref16","first-page":"1404","volume-title":"Methods of Enzymatic Analysis","author":"Wieland","year":"1974"},{"key":"S0007114510004915_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2775"},{"key":"S0007114510004915_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.8.2537"},{"key":"S0007114510004915_ref23","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.6.1290"},{"key":"S0007114510004915_ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030994"},{"key":"S0007114510004915_ref31","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109951"},{"key":"S0007114510004915_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(01)00214-5"},{"key":"S0007114510004915_ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000063079"},{"key":"S0007114510004915_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.8.2235"},{"key":"S0007114510004915_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.09.025"},{"key":"S0007114510004915_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.238"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114510004915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T08:52:52Z","timestamp":1556355172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114510004915\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,4,28]]}},"alternative-id":["S0007114510004915"],"URL":"https:\/\/doi.org\/10.1017\/s0007114510004915","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}