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While overt vitamin B<jats:sub>6<\/jats:sub>deficiency is uncommon in clinical practice, increasing evidence suggests that marginal vitamin B<jats:sub>6<\/jats:sub>deficiency is rather frequent in a consistent proportion of the population and is related to an increased risk of inflammation-related diseases. Ample evidence substantiates the theory of atherosclerosis as an inflammatory disease, and low plasma vitamin B<jats:sub>6<\/jats:sub>concentrations have been related to increased CVD risk. Several studies have also shown that low vitamin B<jats:sub>6<\/jats:sub>status is associated with rheumatoid arthritis and chronic inflammatory bowel diseases, both of which hold an underlying chronic inflammatory condition. Furthermore, the inverse association observed between inflammation markers and vitamin B<jats:sub>6<\/jats:sub>supports the notion that inflammation may represent the common link between low vitamin B<jats:sub>6<\/jats:sub>status and CVD risk. In addition to the epidemiological evidence, there are a number of cell culture and animal studies that have suggested several possible mechanisms relating impaired vitamin B<jats:sub>6<\/jats:sub>status with chronic inflammation. A mild vitamin B<jats:sub>6<\/jats:sub>deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy.<\/jats:p>","DOI":"10.1017\/s0007114511000407","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T08:34:18Z","timestamp":1302683658000},"page":"183-195","source":"Crossref","is-referenced-by-count":91,"title":["Vitamin B<sub>6<\/sub>: a challenging link between nutrition and inflammation in 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