{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:34:55Z","timestamp":1789443295936,"version":"build-2803163510"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T00:00:00Z","timestamp":1305676800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2011,10,28]]},"abstract":"<jats:p>Mg deficiency accelerates Fe accumulation in the liver, which may induce various metabolic disturbances. In the present study, we examined the gene expression of <jats:italic>Hepcidin<\/jats:italic>, a peptide hormone produced in the liver to regulate intestinal Fe absorption negatively, in Mg-deficient rats. Although liver Fe concentration was significantly higher in rats fed an Mg-deficient diet for 4 weeks than in rats fed a control diet, <jats:italic>Hepcidin<\/jats:italic> expression in the liver was comparable between the dietary groups. Previous studies revealed that Fe overload up-regulated <jats:italic>Hepcidin<\/jats:italic> expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth\/differentiation factor belonging to the transforming growth factor-\u03b2 family, in the liver. Mg deficiency up-regulated the expression of <jats:italic>Bmp6<\/jats:italic> but did not affect the expression of inhibition of DNA binding 1, a sensitive Bmp-responsive gene. In addition, the expression of Bmp receptors such as activin receptor-like kinase 2 (<jats:italic>Alk2<\/jats:italic>), activin receptor type IIA (<jats:italic>Actr2a<\/jats:italic>), activin receptor type IIB (<jats:italic>Actr2b<\/jats:italic>) and Bmp type II receptor (<jats:italic>Bmpr2<\/jats:italic>) was lower in the liver of Mg-deficient rats than in that of control rats. The present study indicates that accumulation of hepatic Fe by Mg deficiency is a stimulant inducing <jats:italic>Bmp6<\/jats:italic> expression but not <jats:italic>Hepcidin<\/jats:italic> expression by blunting Bmp signalling possibly resulting from down-regulation of the receptor expression. Unresponsive Hepcidin expression may have a role in Mg deficiency-induced changes related to increased liver Fe.<\/jats:p>","DOI":"10.1017\/s0007114511001553","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T08:29:01Z","timestamp":1305707341000},"page":"1169-1172","source":"Crossref","is-referenced-by-count":10,"title":["Hepcidin expression in the liver of rats fed a magnesium-deficient 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