{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:49:39Z","timestamp":1790135379214,"version":"4.0.1"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T00:00:00Z","timestamp":1309132800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,1,14]]},"abstract":"<jats:p>The natural source of vitamin B<jats:sub>12<\/jats:sub> in human diets comes from animal products. For example, one glass (250\u00a0ml) of milk provides approximately 50\u00a0% of the RDA (2\u00b74\u00a0\u03bcg\/d). It was hypothesised that the provision of vitamin B<jats:sub>12<\/jats:sub> from milk is more efficiently absorbed than the synthetic form used in vitamin supplements. Pigs (<jats:italic>n<\/jats:italic> 10) were used as a model for intestinal absorption of vitamin B<jats:sub>12<\/jats:sub> in humans to compare the net fluxes of vitamin B<jats:sub>12<\/jats:sub> across the portal-drained viscera (PDV; an indicator of intestinal absorption) after ingestion of meals complemented with conventional and vitamin B<jats:sub>12<\/jats:sub>-enriched (via injections to cows) milk (raw, pasteurised or microfiltrated) or with equivalent amounts of cyanocobalamin, the synthetic form used in supplements or unsupplemented. Net flux of vitamin B<jats:sub>12<\/jats:sub> across PDV after the ingestion of milk was positive, though not influenced by milk enrichment (<jats:italic>P<\/jats:italic>&gt;0\u00b73) or technological processes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b78) and was greater than after ingestion of equivalent amounts of cyanocobalamin (cyanocobalamin <jats:italic>v.<\/jats:italic> all milk, <jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00\u00b7003). In fact, net fluxes of this vitamin were not different from 0 after either cyanocobalamin or the meal devoid of vitamin B<jats:sub>12<\/jats:sub> (unsupplemented <jats:italic>v.<\/jats:italic> cyanocobalamin, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b77). The cumulative PDV fluxes during the 24\u00a0h following ingestion of meals complemented with milk varied from 5\u00b75 to 6\u00b78\u00a0\u03bcg. These values correspond to an efficiency of intestinal absorption of vitamin B<jats:sub>12<\/jats:sub> from milk varying between 8 and 10\u00a0%. Therefore, vitamin B<jats:sub>12<\/jats:sub>, which is abundant in cows' milk, is also substantially more available than the most commonly used synthetic form of this vitamin.<\/jats:p>","DOI":"10.1017\/s0007114511002364","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T08:41:22Z","timestamp":1309164082000},"page":"61-66","source":"Crossref","is-referenced-by-count":52,"title":["Bioavailability of vitamin B<sub>12<\/sub> in cows' milk"],"prefix":"10.1017","volume":"107","author":[{"given":"J. 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